Over the past 9 years of COBRE grant support, the Edward C. Carlson Imaging and Image Analysis Core Facility has become an important research resource that supports the microscopic imaging and image analysis requirements of our COBRE grant supported neurodegenerative disease research group as well as other investigators. The Core maintains and provides access to fluorescence, confocal, multiphoton intravital and electron microscopy instrumentation, assists investigators in the design of experiments, develops new applications, and trains investigators in microscopic methods and use of the equipment, and provides core users with information resources related to microscopic imaging. Equipment housed in the Core includes two confocal microscopes, a multiphoton/visible confocal intravital microscope, two fluorescence microscopes, two electron microscopes, and a range of ancillary microscopy equipment. Acquisition of new sophisticated confocal and multiphoton equipment, maintenance of service contracts, support for staff positions, and increased training of investigators in the use of our imaging and image analysis equipment has provided investigators with the ability to employ a range of imaging applications that were not available prior to the COBRE program. The number of publications arising from work performed in the Core has increased to the point where approximately 1/3 of the publications arising from the basic science departments include data collected in the Imaging Core Facility. Moreover, investigators from other parts of campus including the Departments of Biology, Chemistry, and Chemical Engineering as well as from the Energy and Environmental Research Center on the UND campus use the facility. Projects conducted in the Imaging Core Facility investigate a broad range of biomedical issues including protein distribution and expression in cells and tissues, protein-protein interactions, membrane receptor and transporter distribution and function, and cellular and tissue changes as hallmarks of disease pathogenesis. Continued support of this Core will be critical to growing our research enterprise, and will allow the Core to become a sustainable resource that supports research campus-wide as well as elsewhere in the region.

National Institute of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
Center Core Grants (P30)
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Special Emphasis Panel (ZRR1-RI-B (01))
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University of North Dakota
Grand Forks
United States
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Golovko, Svetlana A; Golovko, Mikhail Y (2018) Plasma Unesterified Fatty-Acid Profile Is Dramatically and Acutely Changed under Ischemic Stroke in the Mouse Model. Lipids 53:641-645
Vacano, Guido N; Gibson, David S; Turjoman, Abdullah Arif et al. (2018) Proteomic analysis of six- and twelve-month hippocampus and cerebellum in a murine Down syndrome model. Neurobiol Aging 63:96-109
Quenum Zangbede, Fredice O; Chauhan, Arun; Sharma, Jyotika et al. (2018) Galectin-3 in M2 Macrophages Plays a Protective Role in Resolution of Neuropathology in Brain Parasitic Infection by Regulating Neutrophil Turnover. J Neurosci 38:6737-6750
Sukumaran, Pramod; Sun, Yuyang; Antonson, Neil et al. (2018) Dopaminergic neurotoxins induce cell death by attenuating NF-?B-mediated regulation of TRPC1 expression and autophagy. FASEB J 32:1640-1652
Sun, Yuyang; Selvaraj, Senthil; Pandey, Sumali et al. (2018) MPP+ decreases store-operated calcium entry and TRPC1 expression in Mesenchymal Stem Cell derived dopaminergic neurons. Sci Rep 8:11715
Sharma, Atul; Simonson, Tanner J; Jondle, Christopher N et al. (2017) Mincle-Mediated Neutrophil Extracellular Trap Formation by Regulation of Autophagy. J Infect Dis 215:1040-1048
Geiger, Jonathan D; Chen, Xuesong (2017) Human Immunodeficiency Virus Transactivator of Transcription-Induced Increases in Depression-like Effects Are Linked to Oxidative Stress. Biol Psychiatry Cogn Neurosci Neuroimaging 2:552-553
Krout, Danielle; Rodriquez, Meghan; Brose, Stephen A et al. (2017) Inhibition of the Serotonin Transporter Is Altered by Metabolites of Selective Serotonin and Norepinephrine Reuptake Inhibitors and Represents a Caution to Acute or Chronic Treatment Paradigms. ACS Chem Neurosci 8:1011-1018
Sun, Yuyang; Zhang, Haopeng; Selvaraj, Senthil et al. (2017) Inhibition of L-Type Ca2+ Channels by TRPC1-STIM1 Complex Is Essential for the Protection of Dopaminergic Neurons. J Neurosci 37:3364-3377
Carlson, Edward C; Chhoun, Jennifer M; Grove, Bryon D et al. (2017) Renoprotection From Diabetic Complications in OVE Transgenic Mice by Endothelial Cell Specific Overexpression of Metallothionein: A TEM Stereological Analysis. Anat Rec (Hoboken) 300:560-576

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