The goals for the Multiphoton Microscopy Core Facility are to make advancements on projects that were initiated during the first two phases of the COBRE program and to expand the use of the facility to investigators that require multiphoton microscopy for novel applications, but have limited experience with these techniques. COBRE investigators, in collaboration with other faculty at the Neuroscience Center of Excellence (NCE) have used our multiphoton imaging capabilities to make discoveries in hair cell synapses and plasticity of intrinsic and synaptic properties of dendrites in the hippocampus. The pioneering multiphoton imaging equipment and its applications attracted collaborations that included scientists from outside the Center and University, including Tulane University Medical School. These diverse projects illustrate the applications that can be considered with organized collaboration and core infrastructure. While extending the availability of multiphoton imaging to more researchers in the greater New Orleans area, ultimately the core will attract sufficient new funding, which, in addition to the institutional commitment of the School of Medicine, will make the core self-sufficient by the end of Phase III funding. The three specific aims of this core are: 1) To provide the infrastructure to sustain existing grant projects that listed the core as essential equipment in their NIH applications;2) To utilize the multiphoton facility to implement new research projects;enable collaborations between investigators;create new imaging applications in neuroscience;and help investigators obtain preliminary data for individual grant applications;3) To develop new research strategies by continuing to develop novel capabilities including optogenetics and in vivo imaging.

National Institute of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
Center Core Grants (P30)
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Special Emphasis Panel (ZRR1-RI-B (01))
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Louisiana State Univ Hsc New Orleans
New Orleans
United States
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Elison, Jasmine R; Weinstein, Jessica E; Sheets, Kristopher G et al. (2018) Platelet-Activating Factor (PAF) Receptor Antagonism Modulates Inflammatory Signaling in Experimental Uveitis. Curr Eye Res 43:821-827
Alapure, Bhagwat V; Lu, Yan; Peng, Hongying et al. (2018) Surgical Denervation of Specific Cutaneous Nerves Impedes Excisional Wound Healing of Small Animal Ear Pinnae. Mol Neurobiol 55:1236-1243
Dhingra, Anuradha; Bell, Brent A; Peachey, Neal S et al. (2018) Microtubule-Associated Protein 1 Light Chain 3B, (LC3B) Is Necessary to Maintain Lipid-Mediated Homeostasis in the Retinal Pigment Epithelium. Front Cell Neurosci 12:351
Combe, Crescent L; Canavier, Carmen C; Gasparini, Sonia (2018) Intrinsic Mechanisms of Frequency Selectivity in the Proximal Dendrites of CA1 Pyramidal Neurons. J Neurosci 38:8110-8127
Belayev, Ludmila; Hong, Sung-Ha; Menghani, Hemant et al. (2018) Docosanoids Promote Neurogenesis and Angiogenesis, Blood-Brain Barrier Integrity, Penumbra Protection, and Neurobehavioral Recovery After Experimental Ischemic Stroke. Mol Neurobiol 55:7090-7106
Li, Songhua; Sato, Kota; Gordon, William C et al. (2018) Ciliary neurotrophic factor (CNTF) protects retinal cone and rod photoreceptors by suppressing excessive formation of the visual pigments. J Biol Chem 293:15256-15268
Gao, Jingxia; Hu, Xiao-Dong; Yang, Hongtian et al. (2018) Distinct Roles of Protein Phosphatase 1 Bound on Neurabin and Spinophilin and Its Regulation in AMPA Receptor Trafficking and LTD Induction. Mol Neurobiol 55:7179-7186
Knott, Eric J; Gordon, William C; Jun, Bokkyoo et al. (2018) Retinal Pigment Epithelium and Photoreceptor Preconditioning Protection Requires Docosanoid Signaling. Cell Mol Neurobiol 38:901-917
Bazan, Nicolas G (2018) Docosanoids and elovanoids from omega-3 fatty acids are pro-homeostatic modulators of inflammatory responses, cell damage and neuroprotection. Mol Aspects Med 64:18-33
Gordon, William C; López, Virginia García; Bhattacharjee, Surjyadipta et al. (2018) A Nonsteroidal Novel Formulation Targeting Inflammatory and Pruritus-Related Mediators Modulates Experimental Allergic Contact Dermatitis. Dermatol Ther (Heidelb) 8:111-126

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