A1. OBJECTIVE The overall objective of the Administrative Core is to facilitate the mission of this IDDRC. Thus, the goals of the Administrative Core are to ensure that 1) research in this Center is focused on problems of relevance and importance to intellectual and developmental disabilities, 2) the research is organized around clearly-defined themes, 3) the research is of the highest scientific quality, 4) there is facilitation of multidisciplinary research and research training, 5) translation of basic research findings to clinical application has high priority, and 6) there is fostering of """"""""centerness"""""""", that leads to synergistic, collaborative interactions between IDDRC investigators. We believe that the activities outlined throughout this grant (see Progress Report, Core Descriptions, and Research Projects Proposed for Core Usage) demonstrate that we are achieving these goals, and it is our intention to build upon our previous successes during the next funding period.

National Institute of Health (NIH)
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Center Core Grants (P30)
Project #
Application #
Study Section
Special Emphasis Panel (ZHD1-DSR-Y)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Children's Hospital Boston
United States
Zip Code
Moore, Anna R; Richards, Sarah E; Kenny, Katelyn et al. (2018) Rem2 stabilizes intrinsic excitability and spontaneous firing in visual circuits. Elife 7:
Winawer, Melodie R; Griffin, Nicole G; Samanamud, Jorge et al. (2018) Somatic SLC35A2 variants in the brain are associated with intractable neocortical epilepsy. Ann Neurol 83:1133-1146
Bourassa, Daisy; Elitt, Christopher M; McCallum, Adam M et al. (2018) Chromis-1, a Ratiometric Fluorescent Probe Optimized for Two-Photon Microscopy Reveals Dynamic Changes in Labile Zn(II) in Differentiating Oligodendrocytes. ACS Sens 3:458-467
Leviton, Alan; Joseph, Robert M; Allred, Elizabeth N et al. (2018) Antenatal and Neonatal Antecedents of Executive Dysfunctions in Extremely Preterm Children. J Child Neurol 33:198-208
Hong, Y Kate; Burr, Eliza F; Sanes, Joshua R et al. (2018) Heterogeneity of retinogeniculate axon arbors. Eur J Neurosci :
Chen, Peng; Tao, Liang; Wang, Tianyu et al. (2018) Structural basis for recognition of frizzled proteins by Clostridium difficile toxin B. Science 360:664-669
Fischer, Kathryn D; Houston, Alex C W; Desai, Rajeev I et al. (2018) Behavioral phenotyping and dopamine dynamics in mice with conditional deletion of the glutamate transporter GLT-1 in neurons: resistance to the acute locomotor effects of amphetamine. Psychopharmacology (Berl) 235:1371-1387
Anderson, Matthew P (2018) DEPDC5 takes a second hit in familial focal epilepsy. J Clin Invest 128:2194-2196
Burnett, Alice C; Anderson, Peter J; Joseph, Robert M et al. (2018) Hand Preference and Cognitive, Motor, and Behavioral Functioning in 10-Year-Old Extremely Preterm Children. J Pediatr 195:279-282.e3
Lehrman, Emily K; Wilton, Daniel K; Litvina, Elizabeth Y et al. (2018) CD47 Protects Synapses from Excess Microglia-Mediated Pruning during Development. Neuron 100:120-134.e6

Showing the most recent 10 out of 1442 publications