This program will support the transitional training of pediatric scientists focused on certain aspects of developmental biology. Around this theme, the Department of Pediatrics at the University of Washington School of Medicine, the Children's Hospital and Medical Center, and the Fred Hutchinson Cancer Research Center propose to develop a Child Health Research Center combining the expertise of senior investigators in the Department of Pediatrics with their colleagues and collaborators in the University of Washington system. The objectives of this program are to identify, encourage, and support promising young pediatricians by facilitating their acquisition of the skills and experience required to initiate independent investigative careers. At each research site, a program co-director has been assigned who is a senior scientist within the Department of Pediatrics. Since laboratory research facilities are not centralized, a single, shared core facility would not take full advantage of the extensive resources and facilities at each institution. The goals of our proposed shared core facilities are to facilitate access of the junior investigators to existing core services and provide unique facilities to serve as a focal point for research. Emphasis is placed on new microinjection facilities for the production of transgenic mice and the development of additional capability in confocal microscopy in addition to other techniques and facilities which are available and accessible as purchased core services. There will be two major sources of applicants to the program, our own fellowship programs and our novel efforts to enhance recruitment of minorities. Particular emphasis will be paid to nurturing the careers of female pediatrician scientists. Support from this program. will be the bridge that assures sufficient protected time for pediatrician scientists to successfully apply for FIRST and similar awards and eventually for NIH individual research grants.

National Institute of Health (NIH)
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Center Core Grants (P30)
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Special Emphasis Panel (SRC (04))
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University of Washington
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Parisi, Melissa A; Lipman, Neil S; Clarke, Christine M et al. (2005) Evaluation of Hox11L1 in the fmc/fmc rat model of chronic intestinal pseudo-obstruction. J Pediatr Surg 40:1760-5
Cooper, Laurence J N; Topp, Max S; Pinzon, Cris et al. (2004) Enhanced transgene expression in quiescent and activated human CD8+ T cells. Hum Gene Ther 15:648-58
Leppig, Kathleen A; Sybert, Virginia P; Ross, Judith L et al. (2004) Phenotype and X inactivation in 45,X/46,X,r(X) cases. Am J Med Genet A 128A:276-84
Parisi, Melissa A; Baldessari, Audrey E; Iida, Malissa H K et al. (2003) Genetic background modifies intestinal pseudo-obstruction and the expression of a reporter gene in Hox11L1-/- mice. Gastroenterology 125:1428-40
Weldin, Josh; Jack, Rhona; Dugaw, Kathryn et al. (2003) Quercetin, an over-the-counter supplement, causes neuroblastoma-like elevation of plasma homovanillic acid. Pediatr Dev Pathol 6:547-51
Dinulos, James G H; Mentele, Laurel; Fredericks, L Page et al. (2003) Keratinocyte expression of human beta defensin 2 following bacterial infection: role in cutaneous host defense. Clin Diagn Lab Immunol 10:161-6
Johnston, Donna L; Meshinchi, Soheil; Opheim, Kent E et al. (2003) Progenitor cell involvement is predictive of response to induction chemotherapy in paediatric acute myeloid leukaemia. Br J Haematol 123:431-5
Parisi, Melissa A; Kapur, Raj P; Neilson, Ian et al. (2002) Hydrocephalus and intestinal aganglionosis: is L1CAM a modifier gene in Hirschsprung disease? Am J Med Genet 108:51-6
Bender, M A; Roach, J N; Halow, J et al. (2001) Targeted deletion of 5'HS1 and 5'HS4 of the beta-globin locus control region reveals additive activity of the DNaseI hypersensitive sites. Blood 98:2022-7
Leppig, K A; Disteche, C M (2001) Ring X and other structural X chromosome abnormalities: X inactivation and phenotype. Semin Reprod Med 19:147-57

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