Core BThe Recombinant Technologies Core (Core B) is designed to fulfill critical gaps in core support for projectsrelated to developmental neurobiology. Specifically, this core along with Core C has been designed toserve as a cost-effective, intellectual and technical focal point for the bench scientists who address issues ofnervous system development and function that are germane or directly related to MRDD. The need tointroduce genetic material into their experimental neural or glial preparations is a strategy common to theseinvestigators. The Recombinant Technology Facility provides state-of-the-art technical and personnelsupport for researchers interested in the expression and deletion of genes and other molecules in a varietyof cells and tissues. Such methods are crucial for understanding the mechanisms underlying neuraldevelopment. Through these services, the Core facilitates studies at the molecular level of braindevelopment and function and disease processes, by promoting collaborative projects among MRRCinvestigators and by enabling investigators to combine newly acquired cellular and molecular tools withother approaches, such as electrophysiology and behavior. The advantages of the RecombinantTechnologies Core include shared technical expertise, cost savings, and interactive discussion on the rolesof classes of molecules in development that an individual investigator might not otherwise have appreciatedor been able to evaluate.
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