The major goal of the Physiology Core of the Scripps NeuroAIDS Preclinical Studies (SNAPS), CSPAR, is to? continue to provide neurophysiological assessment of AIDS-related functional pathology using a variety of? established and new animal models with clinical phenotypes relevant for neuroAIDS. The Core services will? include continued evaluation of current primate and feline models infected with the analogous lentivirus (SIV? and FIV, respectively) as well as assessment of existing and new mouse models representing molecularly? engineered phenotypes relevant for HIV-1 infection. The Core will provide a broad spectrum of analyses for? the detection of functional disease progression and identification of underlying mechanisms. In addition, the? Core will work to recruit new SNAPS collaborators who will further enrich the assessment potential of the? Core and its contribution to the neuroAIDS field. The Core is organized into two interacting units that carry? out specific scientific analyses. The analyses provide sensitive measures of disease progression, functional? deficits and underlying mechanisms. The in vivo analysis unit will carry out studies in mouse, primate and? feline models of NeuroAIDS utilizing in vivo techniques including extracellular single unit electrophysiological? recording, sensory potential recording and radio telemetry. The in vitro analysis unit will use? electrophysiological recordings of brain slices from animal models of NeuroAIDS or cultures prepared from? these models. The in vitro unit will also carry out studies of these models using live cell measurement of? cytosolic calcium levels and anatomical studies of receptor expression and localization. Important strengths? of this SNAPS Core include the expertise and knowledge of the faculty and staff, their long-term working? relationships, and their commitment to neuroAIDS research.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Center Core Grants (P30)
Project #
5P30MH062261-08
Application #
7571615
Study Section
Special Emphasis Panel (ZMH1)
Project Start
Project End
Budget Start
2008-03-01
Budget End
2009-02-28
Support Year
8
Fiscal Year
2008
Total Cost
$518,463
Indirect Cost
Name
Scripps Research Institute
Department
Type
DUNS #
781613492
City
La Jolla
State
CA
Country
United States
Zip Code
92037
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