The major goal of the Physiology Core of the Scripps NeuroAIDS Preclinical Studies (SNAPS), CSPAR, is to? continue to provide neurophysiological assessment of AIDS-related functional pathology using a variety of? established and new animal models with clinical phenotypes relevant for neuroAIDS. The Core services will? include continued evaluation of current primate and feline models infected with the analogous lentivirus (SIV? and FIV, respectively) as well as assessment of existing and new mouse models representing molecularly? engineered phenotypes relevant for HIV-1 infection. The Core will provide a broad spectrum of analyses for? the detection of functional disease progression and identification of underlying mechanisms. In addition, the? Core will work to recruit new SNAPS collaborators who will further enrich the assessment potential of the? Core and its contribution to the neuroAIDS field. The Core is organized into two interacting units that carry? out specific scientific analyses. The analyses provide sensitive measures of disease progression, functional? deficits and underlying mechanisms. The in vivo analysis unit will carry out studies in mouse, primate and? feline models of NeuroAIDS utilizing in vivo techniques including extracellular single unit electrophysiological? recording, sensory potential recording and radio telemetry. The in vitro analysis unit will use? electrophysiological recordings of brain slices from animal models of NeuroAIDS or cultures prepared from? these models. The in vitro unit will also carry out studies of these models using live cell measurement of? cytosolic calcium levels and anatomical studies of receptor expression and localization. Important strengths? of this SNAPS Core include the expertise and knowledge of the faculty and staff, their long-term working? relationships, and their commitment to neuroAIDS research.

National Institute of Health (NIH)
National Institute of Mental Health (NIMH)
Center Core Grants (P30)
Project #
Application #
Study Section
Special Emphasis Panel (ZMH1)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Scripps Research Institute
La Jolla
United States
Zip Code
McMillan, JoEllyn; Szlachetka, Adam; Slack, Lara et al. (2018) Pharmacokinetics of a Long-Acting Nanoformulated Dolutegravir Prodrug in Rhesus Macaques. Antimicrob Agents Chemother 62:
Sillman, Brady; Woldstad, Christopher; Mcmillan, Joellyn et al. (2018) Neuropathogenesis of human immunodeficiency virus infection. Handb Clin Neurol 152:21-40
Dave, Rajnish S; Jain, Pooja; Byrareddy, Siddappa N (2018) Functional Meningeal Lymphatics and Cerebrospinal Fluid Outflow. J Neuroimmune Pharmacol 13:123-125
Dyavar, Shetty Ravi; Ye, Zhen; Byrareddy, Siddappa N et al. (2018) Normalization of cell associated antiretroviral drug concentrations with a novel RPP30 droplet digital PCR assay. Sci Rep 8:3626
Ottemann, Brendan M; Helmink, Austin J; Zhang, Wenting et al. (2018) Bioimaging predictors of rilpivirine biodistribution and antiretroviral activities. Biomaterials 185:174-193
Brenza, Timothy M; Schlichtmann, Benjamin W; Bhargavan, Biju et al. (2018) Biodegradable polyanhydride-based nanomedicines for blood to brain drug delivery. J Biomed Mater Res A 106:2881-2890
Sathyanesan, Monica; Watt, Michael J; Haiar, Jacob M et al. (2018) Carbamoylated erythropoietin modulates cognitive outcomes of social defeat and differentially regulates gene expression in the dorsal and ventral hippocampus. Transl Psychiatry 8:113
Zhou, Tian; Su, Hang; Dash, Prasanta et al. (2018) Creation of a nanoformulated cabotegravir prodrug with improved antiretroviral profiles. Biomaterials 151:53-65
Thangaraj, Annadurai; Periyasamy, Palsamy; Liao, Ke et al. (2018) HIV-1 TAT-mediated microglial activation: role of mitochondrial dysfunction and defective mitophagy. Autophagy 14:1596-1619
Kevadiya, Bhavesh D; Ottemann, Brendan M; Thomas, Midhun Ben et al. (2018) Neurotheranostics as personalized medicines. Adv Drug Deliv Rev :

Showing the most recent 10 out of 374 publications