CORE B: GENETICS CORE The purpose of this Core is to provide support for transgenic mouse and zebrafish research. This Core will facilitate current NINDS-funded research and stimulate synergistic Interactions between diverse Investigators using different animal model systems. This support will benefit all investigators by subsidizing costs and providing advanced genome editing services and aquaculture services. The Genetics Core has two components, each with its own faculty Director. I. Transgenic Mice Core Overview The aim of this Core is to support the development of novel mouse models that will facilitate NINDS-funded researchers and stimulate synergistic interactions between Pis in the OSU Neuroscience Center. Because the Core will subsidize the cost of making transgenic and knockout mice, it will support new investigators to develop mouse models which otherwise could be cost prohibitive. This support will be provided by subsidizing costs of generating transgenic and knockout mouse lines and subsidizing the per diems during the initial expansion and characterization phase of the mouse line. Over the 4.5 years of the grant 43 transgenic mice were generated using Core Support benefiting four Pis (Oberdick, Burghes, Obrietan, Yoon). This Core component was cited in twelve papers and led to two new R01s. The projected need for the renewal is forty two transgenics and ten knock outs benefiting ten Pis. Thus, this is a valued, productive Core.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Center Core Grants (P30)
Project #
5P30NS045758-09
Application #
8585892
Study Section
National Institute of Neurological Disorders and Stroke Initial Review Group (NSD)
Project Start
Project End
Budget Start
2013-12-01
Budget End
2014-11-30
Support Year
9
Fiscal Year
2014
Total Cost
$182,038
Indirect Cost
$61,872
Name
Ohio State University
Department
Type
DUNS #
832127323
City
Columbus
State
OH
Country
United States
Zip Code
43210
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Witcher, Kristina G; Bray, Chelsea E; Dziabis, Julia E et al. (2018) Traumatic brain injury-induced neuronal damage in the somatosensory cortex causes formation of rod-shaped microglia that promote astrogliosis and persistent neuroinflammation. Glia 66:2719-2736
Fenn, J Daniel; Johnson, Christopher M; Peng, Juan et al. (2018) Kymograph analysis with high temporal resolution reveals new features of neurofilament transport kinetics. Cytoskeleton (Hoboken) 75:22-41
Ngwenya, Laura B; Mazumder, Sarmistha; Porter, Zachary R et al. (2018) Implantation of Neuronal Stem Cells Enhances Object Recognition without Increasing Neurogenesis after Lateral Fluid Percussion Injury in Mice. Stem Cells Int 2018:4209821

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