This Core has two related components that offer different services. The CNS/PNS Injury Core will provide technical support to generate animal models of Injury and to characterize their behavioral impairment after injury. The Rodent Behavior Core will provide services to test rodent models in standard behavioral paradigms. This Core component also synergizes with the Genetics Core and provides a mechanism to analyze the behavior of transgenic and knockout mice. I. CNS/PSN Nerve Injury Core Overview The study of CNS/PNS nerve Injury is a major strength on the OSU campus. With the services available in this Core, NINDS funded investigators will be able to greatly expand the scope of their work by having easy access to an array of surgical and behavioral techniques which are not typically located together in a single laboratory. This Core will also provide the ability to test novel agents in CNS/PNS Injury models. During the current award nine Pis used this Core resulting in sixteen papers and one new R01.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Center Core Grants (P30)
Project #
5P30NS045758-09
Application #
8585895
Study Section
National Institute of Neurological Disorders and Stroke Initial Review Group (NSD)
Project Start
Project End
Budget Start
2013-12-01
Budget End
2014-11-30
Support Year
9
Fiscal Year
2014
Total Cost
$94,038
Indirect Cost
$28,343
Name
Ohio State University
Department
Type
DUNS #
832127323
City
Columbus
State
OH
Country
United States
Zip Code
43210
Kim, Yangjin; Yoo, Ji Young; Lee, Tae Jin et al. (2018) Complex role of NK cells in regulation of oncolytic virus-bortezomib therapy. Proc Natl Acad Sci U S A 115:4927-4932
Witcher, Kristina G; Bray, Chelsea E; Dziabis, Julia E et al. (2018) Traumatic brain injury-induced neuronal damage in the somatosensory cortex causes formation of rod-shaped microglia that promote astrogliosis and persistent neuroinflammation. Glia 66:2719-2736
Fenn, J Daniel; Johnson, Christopher M; Peng, Juan et al. (2018) Kymograph analysis with high temporal resolution reveals new features of neurofilament transport kinetics. Cytoskeleton (Hoboken) 75:22-41
Ngwenya, Laura B; Mazumder, Sarmistha; Porter, Zachary R et al. (2018) Implantation of Neuronal Stem Cells Enhances Object Recognition without Increasing Neurogenesis after Lateral Fluid Percussion Injury in Mice. Stem Cells Int 2018:4209821
Blissett, A R; Deng, B; Wei, P et al. (2018) Sub-cellular In-situ Characterization of Ferritin(iron) in a Rodent Model of Spinal Cord Injury. Sci Rep 8:3567
Norden, Diana M; Faw, Timothy D; McKim, Daniel B et al. (2018) Bone Marrow-Derived Monocytes Drive the Inflammatory Microenvironment in Local and Remote Regions after Thoracic Spinal Cord Injury. J Neurotrauma :
Sheth, Kajri A; Iyer, Chitra C; Wier, Christopher G et al. (2018) Muscle strength and size are associated with motor unit connectivity in aged mice. Neurobiol Aging 67:128-136
Fenn, J Daniel; Monsma, Paula C; Brown, Anthony (2018) Axonal neurofilaments exhibit frequent and complex folding behaviors. Cytoskeleton (Hoboken) 75:258-280
Hesp, Zoe C; Yoseph, Rim Y; Suzuki, Ryusuke et al. (2018) Proliferating NG2-Cell-Dependent Angiogenesis and Scar Formation Alter Axon Growth and Functional Recovery After Spinal Cord Injury in Mice. J Neurosci 38:1366-1382
Ryu, Jae Cheon; Tooke, Katharine; Malley, Susan E et al. (2018) Role of proNGF/p75 signaling in bladder dysfunction after spinal cord injury. J Clin Invest 128:1772-1786

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