Overview The administrative core will be responsible for overseeing the operation of the Center, including scheduling Steering Committee and Center all-hands meetings, managing training programs, and programming the lecture series. Working closely with the Steering Committee, the Administrative core will establish the Center's overall agenda, set timelines for deliverables, and monitor their progress. The Administrative Core will also lead promotional efforts and a revamped user outreach initiative. Leadership and staff The Administrative Core will be led by Mark Mintun. Dr. Mintun is the Mallinckrodt Institute of Radiology (MIR) Division Director of Research Development and interim Director of Radiological Sciences which includes the NIL and Cyclotron Facility. He is also the Director of the CCIR and of the imaging component of the Clinical and Translational Science Award (CTSA). In 2006, he was the PI of a High End Instrumentation grant to purchase a Siemens Biograph PET/CT (which is in the CCIR). Dr. Mintun, with Dr. Marcus Raichle, developed methods to image and quantitate oxygen metabolism and receptor availability in vivo (coining the term Binding Potential), and conducted pioneering work in methods to map brain function. Patricia Aldea will serve as the NCCBI's user outreach specialist. This newly created position, which is described in detail below, is being established in direct response to user feedback that additional support is required for them to optimally use the Center's resource. A software engineer will provide algorithm, application, and visualization development. This position will be funded by the Department of Radiology, as described in the letter from Dr. Jost, allowing the engineer to contribute to the Center in ways that compliment the allowable costs described in the RFA.

National Institute of Health (NIH)
National Institute of Neurological Disorders and Stroke (NINDS)
Center Core Grants (P30)
Project #
Application #
Study Section
National Institute of Neurological Disorders and Stroke Initial Review Group (NSD)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Washington University
Saint Louis
United States
Zip Code
Roe, Catherine M; Babulal, Ganesh M; Stout, Sarah H et al. (2018) Using the A/T/N Framework to Examine Driving in Preclinical AD. Geriatrics (Basel) 3:
Su, Yi; Flores, Shaney; Hornbeck, Russ C et al. (2018) Utilizing the Centiloid scale in cross-sectional and longitudinal PiB PET studies. Neuroimage Clin 19:406-416
Roe, Catherine M; Ances, Beau M; Head, Denise et al. (2018) Incident cognitive impairment: longitudinal changes in molecular, structural and cognitive biomarkers. Brain 141:3233-3248
Lee, Seonjoo; Zimmerman, Molly E; Narkhede, Atul et al. (2018) White matter hyperintensities and the mediating role of cerebral amyloid angiopathy in dominantly-inherited Alzheimer's disease. PLoS One 13:e0195838
Chhatwal, Jasmeer P; Schultz, Aaron P; Johnson, Keith A et al. (2018) Preferential degradation of cognitive networks differentiates Alzheimer's disease from ageing. Brain 141:1486-1500
Franzmeier, Nicolai; Düzel, Emrah; Jessen, Frank et al. (2018) Left frontal hub connectivity delays cognitive impairment in autosomal-dominant and sporadic Alzheimer's disease. Brain 141:1186-1200
Sato, Chihiro; Barthélemy, Nicolas R; Mawuenyega, Kwasi G et al. (2018) Tau Kinetics in Neurons and the Human Central Nervous System. Neuron 98:861-864
Gordon, Brian A; Blazey, Tyler M; Su, Yi et al. (2018) Spatial patterns of neuroimaging biomarker change in individuals from families with autosomal dominant Alzheimer's disease: a longitudinal study. Lancet Neurol 17:241-250
Villeneuve, Sylvia; Vogel, Jacob W; Gonneaud, Julie et al. (2018) Proximity to Parental Symptom Onset and Amyloid-? Burden in Sporadic Alzheimer Disease. JAMA Neurol 75:608-619
Sato, Chihiro; Barthélemy, Nicolas R; Mawuenyega, Kwasi G et al. (2018) Tau Kinetics in Neurons and the Human Central Nervous System. Neuron 97:1284-1298.e7

Showing the most recent 10 out of 155 publications