Applications of magnetic resonance (MR) techniques to research in the life sciences are growing rapidly. State-of-the-art heteronuclear MR spectroscopy (MRS) and multi-modal MR imaging (MRI) methodologies cultivated at the Magnetic Resonance Research Center (MRRC) at Yale have moved in vivo animal research into central roles in experimental neuroscience, addressing fundamental issues with far reaching implications for brain function. Since the formation of the Yale MRRC in the early in 1980s, the number of . horizontal-bore magnets for in vivo studies have multiplied three-fold in 2004. The present number of ' magnets for in vivo studies - three each for animals and humans - were needed to match the growing number of investigators across many disciplines - a majority of whom are supported by NINDS. The strength of the Yale MRRC has been, and still is, the dynamic interaction between rodent and human research. Active interplay between heteronuclear MRS and multi-modal MRI methods in rodents and humans have furthermore rapidly progressed. Because MR technology requires unwavering infrastructural support for state-of-the-art exploits to be successfully applied, long-term stability of Yale MRRC is contingent on sustained support. A program in """"""""Quantitative Neuroscience with Magnetic Resonance (QNMR)"""""""" at Yale will support shared resources and facilities used by NINDS-funded investigators at Yale, and thereby generate greater productivity than would be possible via independent efforts. QNMR will consist of three research Cores - each dedicated to improving effectiveness of ongoing research based upon multimodal MRI, heteronuclear MRS, neurophysiology - and one service Core - designed for rapid data analysis, access, sharing, and backup using high-performance cluster of workstations. We expect that QNMR will promote a more cooperative and interactive research environment for neuroscientists who are utilizing MR technology at Yale, and will nurture new cross-disciplinary approaches in medicine, physiology, and neuroscience.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Center Core Grants (P30)
Project #
5P30NS052519-05
Application #
8374449
Study Section
National Institute of Neurological Disorders and Stroke Initial Review Group (NSD)
Project Start
Project End
2013-11-30
Budget Start
2011-12-01
Budget End
2012-11-30
Support Year
5
Fiscal Year
2012
Total Cost
$246,026
Indirect Cost
$97,370
Name
Yale University
Department
Type
DUNS #
043207562
City
New Haven
State
CT
Country
United States
Zip Code
06520
Benveniste, Helene; Dienel, Gerald; Jacob, Zvi et al. (2018) Trajectories of Brain Lactate and Re-visited Oxygen-Glucose Index Calculations Do Not Support Elevated Non-oxidative Metabolism of Glucose Across Childhood. Front Neurosci 12:631
Thompson, Garth J; Sanganahalli, Basavaraju G; Baker, Keeley L et al. (2018) Spontaneous activity forms a foundation for odor-evoked activation maps in the rat olfactory bulb. Neuroimage 172:586-596
Yu, Yuguo; Herman, Peter; Rothman, Douglas L et al. (2018) Evaluating the gray and white matter energy budgets of human brain function. J Cereb Blood Flow Metab 38:1339-1353
Johnson, Matthew B; Sun, Xingshen; Kodani, Andrew et al. (2018) Aspm knockout ferret reveals an evolutionary mechanism governing cerebral cortical size. Nature 556:370-375
Johnson, Frances K; Delpech, Jean-Christophe; Thompson, Garth J et al. (2018) Amygdala hyper-connectivity in a mouse model of unpredictable early life stress. Transl Psychiatry 8:49
Mortensen, Kristian N; Gjedde, Albert; Thompson, Garth J et al. (2018) Impact of Global Mean Normalization on Regional Glucose Metabolism in the Human Brain. Neural Plast 2018:6120925
Thompson, Garth J (2018) Neural and metabolic basis of dynamic resting state fMRI. Neuroimage 180:448-462
Wang, Helen; Huang, Yuegao; Coman, Daniel et al. (2017) Network evolution in mesial temporal lobe epilepsy revealed by diffusion tensor imaging. Epilepsia 58:824-834
de Graaf, Robin A; De Feyter, Henk M; Brown, Peter B et al. (2017) Detection of cerebral NAD+ in humans at 7T. Magn Reson Med 78:828-835
Prinsen, Hetty; de Graaf, Robin A; Mason, Graeme F et al. (2017) Reproducibility measurement of glutathione, GABA, and glutamate: Towards in vivo neurochemical profiling of multiple sclerosis with MR spectroscopy at 7T. J Magn Reson Imaging 45:187-198

Showing the most recent 10 out of 149 publications