Renewal of the NCRR Center for Advanced Magnetic Resonance Technology is proposed. Magnetic resonance instrument manufacturers Introduce new technology in their products based on marketing and other factors that often preclude the timely availability of cutting edge research capabilities for investigators. To fill this gap, the Center will develop and make available innovative technologies in five core research areas of magnetic resonance imaging and spectroscopy (MRI/MRS): (1) image reconstruction, fast imaging and RF pulse design methods, (2) MR hardware, (3) body imaging methods, (4) neuroimaging methods, and (5) MR spectroscopy methods. In each of these areas, we will capitalize on the extensive experience in Stanford's Radiology and Electrical Engineering departments to improve and expand imaging technology for use in basic research and clinical care, and to provide cutting edge opportunities for biomedical research with MRI.. Over the past five years, the Center has been motivated by and has served a wide base of extramurally sponsored collaborators and service users from leading medical and research institutions. We will continue to nurture these collaborations and mutually enrich our research and development efforts. Examples of collaborative projects today are the development and use of advanced functional MRI imaging methods in neurosciences and clinical applications and studies of breast cancer with efficient MRS methods. We will continue to train students and postdoctoral fellows to be the future leaders in MR, to publish extensively, and to provide educational opportunities to the scientific and medical communities we serve. New technology and technological capabilities developed at the Center and as part of our extensive collateral research will be disseminated rapidly for widespread use in the national research community. Publications, conference presentations, annual reports and the internet will continue to form the backbone of our dissemination efforts.

Public Health Relevance

Historically, the introduction of new MRI/MRS methods has had a profound impact on public health research. Unfortunately, many researchers do not have access to the latest MR technology because vendors'priorities often preclude their inclusion. CAMRT's record of accomplishment and the ever-evolving need for timely new technology of the type we propose compel the continuation of CAMRT as a national research resource.

Agency
National Institute of Health (NIH)
Institute
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
Type
Biotechnology Resource Grants (P41)
Project #
8P41EB015891-18
Application #
8255467
Study Section
Special Emphasis Panel (ZRG1-SBIB-U (40))
Program Officer
Liu, Guoying
Project Start
1997-01-01
Project End
2015-03-31
Budget Start
2012-04-01
Budget End
2013-03-31
Support Year
18
Fiscal Year
2012
Total Cost
$1,283,273
Indirect Cost
$477,897
Name
Stanford University
Department
Radiation-Diagnostic/Oncology
Type
Schools of Medicine
DUNS #
009214214
City
Stanford
State
CA
Country
United States
Zip Code
94305
Weber, Hans; Hargreaves, Brian A; Daniel, Bruce L (2018) Artifact-reduced imaging of biopsy needles with 2D multispectral imaging. Magn Reson Med 80:655-661
Gibbons, Eric K; Vasanawala, Shreyas S; Pauly, John M et al. (2018) Body diffusion-weighted imaging using magnetization prepared single-shot fast spin echo and extended parallel imaging signal averaging. Magn Reson Med 79:3032-3044
Tian, Qiyuan; Wintermark, Max; Jeffrey Elias, W et al. (2018) Diffusion MRI tractography for improved transcranial MRI-guided focused ultrasound thalamotomy targeting for essential tremor. Neuroimage Clin 19:572-580
Weber, Hans; Ghanouni, Pejman; Pascal-Tenorio, Aurea et al. (2018) MRI monitoring of focused ultrasound sonications near metallic hardware. Magn Reson Med 80:259-271
Hegarty 2nd, John P; Gu, Meng; Spielman, Daniel M et al. (2018) A proton MR spectroscopy study of the thalamus in twins with autism spectrum disorder. Prog Neuropsychopharmacol Biol Psychiatry 81:153-160
Srinivasan, Subashini; Hargreaves, Brian A; Daniel, Bruce L (2018) Fat-based registration of breast dynamic contrast enhanced water images. Magn Reson Med 79:2408-2414
Yoruk, Umit; Hargreaves, Brian A; Vasanawala, Shreyas S (2018) Automatic renal segmentation for MR urography using 3D-GrabCut and random forests. Magn Reson Med 79:1696-1707
Terem, Itamar; Ni, Wendy W; Goubran, Maged et al. (2018) Revealing sub-voxel motions of brain tissue using phase-based amplified MRI (aMRI). Magn Reson Med 80:2549-2559
Levine, Evan; Hargreaves, Brian (2018) On-the-Fly Adaptive ${k}$ -Space Sampling for Linear MRI Reconstruction Using Moment-Based Spectral Analysis. IEEE Trans Med Imaging 37:557-567
Hargreaves, Brian A; Taviani, Valentina; Litwiller, Daniel V et al. (2018) 2D multi-spectral imaging for fast MRI near metal. Magn Reson Med 79:968-973

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