TRD 1 The proposed research in TRD Project 1 is to develop novel optical coherence tomography (OCT)-based techniques and tools for measuring the mechanical properties and parameters as well as acoustic transduction in tissues. The focus on tissue biomechanics responds to the emerging opportunity to harness OCT's unique capabilities to obtain quantitative maps of tissue vibration, deformation, strain, and force at high precision and high spatiotemporal resolution.
Specific aims are directly motivated by the challenges identified in Collaborative Projects.
Aim 1 is to develop probe-based OCT vibrography for analysis of middle and inner ears. A cellular- resolution probe with a diameter of 1 mm will be developed, tested, and validated in vivo with genetically modified mouse models of hearing disorders. Furthermore, the ability to image the 3D structure and sound- driven vibration of the inner working of human cochlea in cadaveric specimens will be established.
Aim 2 of the proposed research is to develop corneal elastography based on noncontact acoustic vibration. Finite-element methods to map corneal stiffness from vibrational images will be developed and tested in a pilot human study involving normal and LASIK-treated subjects.
Aim 3 of TRD-1 is to develop micro-sized inclusion sensors for OCT elastography for mapping force, strain, and stiffness with greatly enhanced accuracy. This tool and computational algorithm will be tested for quantitative biomechanics mapping of the optic nerve head. Through these combined aims, TRD-1 strives to help the community advance fundamental knowledge and improve the diagnosis and treatments of diseases through technical innovations.
TRD 1 Imaging technologies that can measure the softness and hardness of tissue, and the force and strain to tissue can provide highly useful diagnostic information about health and diseases. Such technologies may enable early diagnosis of problems in hearing and vision and help improve their treatments.
|Nam, Ahhyun S; Easow, Jeena M; Chico-Calero, Isabel et al. (2018) Wide-Field Functional Microscopy of Peripheral Nerve Injury and Regeneration. Sci Rep 8:14004|
|Cuartas-Vélez, Carlos; Restrepo, René; Bouma, Brett E et al. (2018) Volumetric non-local-means based speckle reduction for optical coherence tomography. Biomed Opt Express 9:3354-3372|
|Braaf, Boy; Donner, Sabine; Nam, Ahhyun S et al. (2018) Complex differential variance angiography with noise-bias correction for optical coherence tomography of the retina. Biomed Opt Express 9:486-506|
|Uribe-Patarroyo, Néstor; Kassani, Sahar Hosseinzadeh; Villiger, Martin et al. (2018) Robust wavenumber and dispersion calibration for Fourier-domain optical coherence tomography. Opt Express 26:9081-9094|
|Villiger, Martin; Otsuka, Kenichiro; Karanasos, Antonios et al. (2018) Coronary Plaque Microstructure and Composition Modify Optical Polarization: A New Endogenous Contrast Mechanism for Optical Frequency Domain Imaging. JACC Cardiovasc Imaging 11:1666-1676|
|Inoue, Yoshitaka; Liu, Yuk Ming; Otawara, Masayuki et al. (2018) Resolvin D2 Limits Secondary Tissue Necrosis After Burn Wounds in Rats. J Burn Care Res 39:423-432|
|Villiger, Martin; Otsuka, Kenichiro; Karanasos, Antonios et al. (2018) Repeatability Assessment of Intravascular Polarimetry in Patients. IEEE Trans Med Imaging 37:1618-1625|
|Jones, Dennis; Meijer, Eelco F J; Blatter, Cedric et al. (2018) Methicillin-resistant Staphylococcus aureus causes sustained collecting lymphatic vessel dysfunction. Sci Transl Med 10:|
|Bouta, Echoe M; Blatter, Cedric; Ruggieri, Thomas A et al. (2018) Lymphatic function measurements influenced by contrast agent volume and body position. JCI Insight 3:|
|Siddiqui, Meena; Nam, Ahhyun S; Tozburun, Serhat et al. (2018) High-speed optical coherence tomography by circular interferometric ranging. Nat Photonics 12:111-116|
Showing the most recent 10 out of 134 publications