Abstract

Self assembly techniques are being used to adsorb organic thin films onto gold and oxide surfaces. Both monomeric and polymeric components are used to form the organic thin films. The monomeric assemblies are comprised of alkane thiols (gold) and silanes (oxides) with varying degrees of fluorination. For thiols, the effect of the length of the fluorocarbon and hydrocarbon sections on assembly, orientation, and bonding in the resulting organic thin film is being examined. Initially films containing only one type of monomer are being examined [e.g., CF3(CF2)7(CH2)11SH]. In the future thin films prepared from mixtures of different monomers will also be examined. For silanes, the effect of surface coverage on chain orientation for vapor deposited fluorinated compounds [e.g., CF3(CF2)7(CH2)2SiCl3] is being examined. The polymeric system currently being studied is a dimethyl siloxane with three different concentrations of propyl thiol side chains. Film thickness, thiol dis tribution within the organic thin film, percent of thiol groups bound to the gold surface, and oxidation of the unbound thiol groups are being examined.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Biotechnology Resource Grants (P41)
Project #
5P41RR001296-16
Application #
6345049
Study Section
Project Start
2000-09-01
Project End
2001-08-31
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
16
Fiscal Year
2000
Total Cost
$24,542
Indirect Cost

  Institution

Name
University of Washington
Department
Type
DUNS #
135646524
City
Seattle
State
WA
Country
United States
Zip Code
98195

  Publications

Tyler, Bonnie J; Peterson, Richard E (2013) Dead-time correction for time-of-flight secondary-ion mass spectral images: a critical issue in multivariate image analysis. Surf Interface Anal 45:475-478
Tyler, B J; Bruening, C; Rangaranjan, S et al. (2011) TOF-SIMS imaging of adsorbed proteins on topographically complex surfaces with Bi(3) (+) primary ions. Biointerphases 6:135
Medzihradszky, Katalin F (2008) Characterization of site-specific N-glycosylation. Methods Mol Biol 446:293-316
Medzihradszky, Katalin F (2005) Peptide sequence analysis. Methods Enzymol 402:209-44
Sanders, Joan E; Lamont, Sarah E; Karchin, Ari et al. (2005) Fibro-porous meshes made from polyurethane micro-fibers: effects of surface charge on tissue response. Biomaterials 26:813-8
Medzihradszky, Katalin F (2005) In-solution digestion of proteins for mass spectrometry. Methods Enzymol 405:50-65
Medzihradszky, Katalin F (2005) Characterization of protein N-glycosylation. Methods Enzymol 405:116-38
Cheng, Xuanhong; Wang, Yanbing; Hanein, Yael et al. (2004) Novel cell patterning using microheater-controlled thermoresponsive plasma films. J Biomed Mater Res A 70:159-68
Wagner, Victoria E; Koberstein, Jeffrey T; Bryers, James D (2004) Protein and bacterial fouling characteristics of peptide and antibody decorated surfaces of PEG-poly(acrylic acid) co-polymers. Biomaterials 25:2247-63
Tsai, W B; Shi, Q; Grunkemeier, J M et al. (2004) Platelet adhesion to radiofrequency glow-discharge-deposited fluorocarbon polymers preadsorbed with selectively depleted plasmas show the primary role of fibrinogen. J Biomater Sci Polym Ed 15:817-40

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