Adhesive interactions among leukocytes and between leukocytes and endothelium are central to processes of inflammation.These interactions are mediated by sequential molecular steps involving carbohydrates and selectins, and integrins and ICAMs. We are presently using flow cytometry to examine the interaction of neutrophils with cells transfected with ICAM, a counter structure for the neutrophil integrins. A manuscript is in preparation for submission to J. Immunol. Next year we will extend this approach to exmaine the mechanisms of aggregation of lymphoma cells which may contribute to leukostasis.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Biotechnology Resource Grants (P41)
Project #
5P41RR001315-14
Application #
5223192
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
14
Fiscal Year
1996
Total Cost
Indirect Cost
Frumkin, Jesse P; Patra, Biranchi N; Sevold, Anthony et al. (2016) The interplay between chromosome stability and cell cycle control explored through gene-gene interaction and computational simulation. Nucleic Acids Res 44:8073-85
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