Abstract

THE NON-INVASIVE VIBRATING ION-SELECTIVE PROBES WILL ALLOW THE STUDY OF TOXINS DIRECTED AGAINST CELLULAR HOMEOSTASIS AND THE MECHANISMS BEHIND ~STEADY-STATE~ ION FLUX. NOT ONLY DO WE EXPECT THIS TO BE USEFUL IN THE ANALYSIS OF TOXIN ACTION BUT WE ALSO EXPECT TO ISOLATE COMPOUNDS OF USE TO THE BIOMEDICAL COMMUNITY. MANY OF THE COMPOUNDS USED IN MODERN NEUROBIOLOGY AND CELL BIOLOGY TO STUDY ION MOVEMENTS, SIGNAL TRANSDUCTION, SECRETION AND OTHERS, ARE ISOLATED FROM LIVING MATERIAL. DR. SHIMIZU~S LAB HAS A LONG HISTORY OF ISOLATING NATURAL PRODUCTS FROM THE MARINE ENVIRONMENT WHICH ACT ON CELL PHYSIOLOGY AND REPLICATION. HIS COMPOUNDS ARE ROUTINELY SCREENED FOR THEIR ANTI-CANCER ACTION. IN ADDITION SHIMIZU HAS AN INTEREST IN UNDERSTANDING THE PHYSIOLOGICAL MECHANISMS UNDERLYING SUCH ACTIONS. TO FACILITATE THIS HE HAS BEGUN WHAT WE FORESEE AS A LONG-TERM COLLABORATION WITH THE NVPF. DR. SHIMIZU HOLDS AN NIH MERIT AWARD.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Biotechnology Resource Grants (P41)
Project #
3P41RR001395-14S1
Application #
5223352
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
14
Fiscal Year
1996
Total Cost
Indirect Cost

  Publications

Demidenko, Eugene; Glaholt, S P; Kyker-Snowman, E et al. (2017) Single toxin dose-response models revisited. Toxicol Appl Pharmacol 314:12-23
Chowanadisai, Winyoo; Messerli, Shanta M; Miller, Daniel H et al. (2016) Cisplatin Resistant Spheroids Model Clinically Relevant Survival Mechanisms in Ovarian Tumors. PLoS One 11:e0151089
De Martino, Federico; Moerel, Michelle; Ugurbil, Kamil et al. (2015) Less noise, more activation: Multiband acquisition schemes for auditory functional MRI. Magn Reson Med 74:462-7
Van Mooy, Benjamin A S; Hmelo, Laura R; Fredricks, Helen F et al. (2014) Quantitative exploration of the contribution of settlement, growth, dispersal and grazing to the accumulation of natural marine biofilms on antifouling and fouling-release coatings. Biofouling 30:223-36
Brodsky, Alexander S; Fischer, Andrew; Miller, Daniel H et al. (2014) Expression profiling of primary and metastatic ovarian tumors reveals differences indicative of aggressive disease. PLoS One 9:e94476
De Martino, Federico; Zimmermann, Jan; Muckli, Lars et al. (2013) Cortical depth dependent functional responses in humans at 7T: improved specificity with 3D GRASE. PLoS One 8:e60514
De Martino, Federico; Moerel, Michelle; van de Moortele, Pierre-Francois et al. (2013) Spatial organization of frequency preference and selectivity in the human inferior colliculus. Nat Commun 4:1386
Vang, Souriya; Wu, Hsin-Ta; Fischer, Andrew et al. (2013) Identification of ovarian cancer metastatic miRNAs. PLoS One 8:e58226
Chowanadisai, Winyoo; Graham, David M; Keen, Carl L et al. (2013) Neurulation and neurite extension require the zinc transporter ZIP12 (slc39a12). Proc Natl Acad Sci U S A 110:9903-8
Graham, David M; Messerli, Mark A; Pethig, Ronald (2012) Spatial manipulation of cells and organelles using single electrode dielectrophoresis. Biotechniques 52:39-43

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