This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.Oocyte senescence or germ cell depletion and dysfunction, accompanied by ovarian atrophy and aberrant endocrine profiles, make a major contribution to premature reproductive aging, including infertility and menopause. My laboratory focuses on mechanisms of oocyte senescence-associated infertility resulting from reproductive aging as well as environmental toxicity, and development of novel approaches to delay or reverse oocyte senescence. Our three specific research projects are to: 1) understand defects in meiosis caused by reproductive age using knockout and naturally aging mouse as models; 2) investigate how cigarette smoke affects oocyte and embryo development; and 3) develop competent specialized stem cells that can be used to replenish oocytes and recover ovarian function, and for other purposes in regenerative medicine in general.This lab is in transition from MBL to South Florida. It remains to be seen how involved it will be with the BRC over the coming years.
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