We are studying the formation of a complex neural network that innervates the skin of embryonic zebrafish. Rohon-Beard cells make an extensively branched projection pattern into the periphery. We are trying to determine the rules that regulate that projection pattern: for instance, we suspect that there must be a fine balance of attraction and repulsion between arrays of growing axons to prevent either collapse of the net into an adhesive knot or restriction of the axons into non-crossing domains. 8-31-96

National Institute of Health (NIH)
National Center for Research Resources (NCRR)
Biotechnology Resource Grants (P41)
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Deng, Manqi; Williams, Carmen J; Schultz, Richard M (2005) Role of MAP kinase and myosin light chain kinase in chromosome-induced development of mouse egg polarity. Dev Biol 278:358-66
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