PAH when reduced, reacts with NO. The EPR, extending from g = 4 to g = 2 is indicative of an S = 3/2 system. The cw EPR is perturbed by either substrate or pterin addition. ESEEM studies show weak modulations from 14N that disappear in samples that are allowed to anneal. Studies to be carried out will be addressed at demonstrating interaction with substrate and/or cofactors using deuterated materials.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Biotechnology Resource Grants (P41)
Project #
5P41RR002583-13
Application #
6281734
Study Section
Project Start
1998-05-05
Project End
2000-04-30
Budget Start
1997-10-01
Budget End
1998-09-30
Support Year
13
Fiscal Year
1998
Total Cost
Indirect Cost
Name
Albert Einstein College of Medicine
Department
Type
DUNS #
009095365
City
Bronx
State
NY
Country
United States
Zip Code
10461
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