This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.This interaction has two components. First this group has developed new high-sensitivity NMR for mass-limited samples, for example the 750 MHz 1 mm triple resonance solenoid with a 1.2 l active volume, and the high temperature superconducting probe. Second, PARACEST at high fields (where long T1 and chemical shift dispersion are both improved) will be explored. The research program at the University of Florida seems tailor-made for close coordination with the goals of the UTSW NMR Center for In Vivo Metabolism. Each of the technological developments of this lab work directly towards lowering the detection limits of NMR using novel probe technologies. With the addition of the more sensitive probes, the analyzing power for metabolomics studies will multiply. For example, the low levels of isotopic enrichments achievable in humans means that these metabolic measurements will benefit from increased sensitivity. The lower detection limits will make time course studies easier to carry out, since smaller samples will produce acceptable data.
Showing the most recent 10 out of 374 publications
