This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Asialoglycoprotein receptor (ASGP-R) is a member of the C-type animal lectin family and is located on liver parenchymal cells. It was originally identified and characterized on the basis of its ability to bind glycoproteins bearing terminal galactose or N-acetyl galactosamine residues. However, endogenous ligands for ASGP-R have not been definitely identified. We are investigating the binding modes of rat ASGP-R and its affinity for oligosaccharides terminating with Sia-(2,6)-GalNAc-beta(1,4)-GlcNAc by using X-ray crystallography.
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