DNA and protein sequence analysis programs (including the GCG package) on the supercomputer will be used to analyze and interpret the DNA sequence of mycobacteriophage L5. The entire DNA sequence (52, 297bp) has recently been determined by us, and we are attempting to identify L5 genes and functions of the gene products. This information is useful for understanding the molecular genetics of the mycobacteria, including Mycobacetrium tuberculosis and Mycobacterim leprae. We are currently manipulating the L5 genome to construct recombinant BCG vaccines and to develop tools for rapid diagnosis of tuberculosis.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Biotechnology Resource Grants (P41)
Project #
3P41RR006009-09
Application #
6282459
Study Section
Project Start
1998-08-01
Project End
1999-07-31
Budget Start
1997-10-01
Budget End
1998-09-30
Support Year
9
Fiscal Year
1998
Total Cost
Indirect Cost
Name
Mellon Pitts Corporation (Mpc Corp)
Department
Type
DUNS #
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213
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