We have determined the DNA sequence of one bacteriophage genome and will determine about ten more, and roughly 15 more are available in public databases. We will use PSC facilities to assemble our DNA sequence data to produce finished sequences and then to analyze those sequences. Analysis will include, first, analysis of individual genome sequences to determine the genetic structure of the individual viruses and , second, comparisions among the newly determined sequences and other DNA sequences in the GenBank database In particular, we will focus on comparisons between related bacteriophage sequences, at the level of individual genes and proteins and at the level of the entire genomes. Information from these comparisons will address issues of structure/function relationships in the viral proteins and of genetic mechanisms operating in the evolution of viral genomes.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Biotechnology Resource Grants (P41)
Project #
3P41RR006009-09S1
Application #
6295113
Study Section
Project Start
1998-09-30
Project End
1999-07-31
Budget Start
1997-10-01
Budget End
1998-09-30
Support Year
9
Fiscal Year
1998
Total Cost
Indirect Cost
Name
Mellon Pitts Corporation (Mpc Corp)
Department
Type
DUNS #
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213
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