The overall mission of the National BiomedicalComputation Resource is to conduct, catalyze and enable biomedical research by harnessing forefront computational and information technologies. The key aim of this resource is to provide transparent access to the new and emerging grid infrastructure that will deliver integrated compute, data, physical, experimental, and human resources to biomedical scientists investigating a wide range of medically important problems spanning scales of biological organization from small molecule drug design and comparative genomics to diagnostic brain imaging and cardiovascular disease. To achieve this aim, this resource will:1. Integrate computational data and visualization resources in a transparent, advanced gridenvironment to enable better access to distributed data, computational resources, instrumentsand people.2. Develop and deploy advanced computational tools for modeling and simulation, data analysis,query and integration, three-dimensional image processing, and interactive visualization.3. Deliver and support advanced grid/Cyber-infrastructure for biomedical researchers.4. Train a cadre of new researchers such that they have an interdisciplinary, working knowledge both of experimental biology and of computational technology relevant to biomedical scientists.The core technology research will bring together key grid technologies and address biomedicalproblems that span scales and focus understanding on the relationship between sequence structure and function. The collaborative service, training and dissemination components all relate to expanding the use of these technologies. The core projects include:*Computational grid-enable approaches for simulating and integrating multi-scale, sub-cellularprocesses, from ab initio quantum mechanics to continuum mechanics.*Data integration and grid-enabled analytic tools for molecular sequences to integrated datasources to created a data laboratory.*Structurally and functionally integrated, grid-aware modeling of cell and organ biophysics.*Visual environments for multi-scale biomedical modeling.*Grid computing and analysis services for multi-scale biomedical applications.Given the scope of the proposed activities, the NBCR will deliver innovative software tools and grid- accessible resources covering different scales of biomedical research.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Biotechnology Resource Grants (P41)
Project #
5P41RR008605-12
Application #
7182026
Study Section
Special Emphasis Panel (ZRG1-SSS-9 (40))
Project Start
2005-05-01
Project End
2006-04-30
Budget Start
2005-05-01
Budget End
2006-04-30
Support Year
12
Fiscal Year
2005
Total Cost
$3,460
Indirect Cost
Name
University of California San Diego
Department
Anatomy/Cell Biology
Type
Schools of Arts and Sciences
DUNS #
804355790
City
La Jolla
State
CA
Country
United States
Zip Code
92093
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Morgan, Ashley E; Wozniak, Curtis J; Gulati, Sarthak et al. (2017) Association of Uneven MitraClip Application and Leaflet Stress in a Finite Element Model. JAMA Surg 152:111-114
Morgan, Ashley E; Pantoja, Joe L; Grossi, Eugene A et al. (2016) Neochord placement versus triangular resection in mitral valve repair: A finite element model. J Surg Res 206:98-105
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Ge, Liang; Wu, Yife; Soleimani, Mehrdad et al. (2016) Moderate Ischemic Mitral Regurgitation After Posterolateral Myocardial Infarction in Sheep Alters Left Ventricular Shear but Not Normal Strain in the Infarct and Infarct Borderzone. Ann Thorac Surg 101:1691-9
Morgan, Ashley E; Pantoja, Joe Luis; Weinsaft, Jonathan et al. (2016) Finite Element Modeling of Mitral Valve Repair. J Biomech Eng 138:021009

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