This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.Recently, steady state free precession (SSFP) chemical shift imaging techniques have been introduced which are particularly attractive because of their short measurement time (Tacq) and high sensitivity (SNR/Tacq). The main disadvantages of SSFP-based methods are that the effects of both T1 and T2 on the signal intensities complicate quantitation and the spectral resolution is limited due to the short TRs. Whereas the former is an inherent problem, the latter is less problematic at high field strengths such as 7 T due to the increased dispersion of the chemical shift. Spectroscopic missing pulse SSFP (spMP-SSFP) has the advantage that the full echo can be acquired. This allows data to be analyzed in magnitude mode without spectral line broadening. Therefore, the aim of this work was to implement spMP-SSFP with a spectral-spatial radiofrequency pulse for combined water and lipid suppression at 7 T. The higher field strength provides better signal separation and higher SNR relative to low- and midfield systems. Even when using a relatively small flip angle (45 ) with the currently available RF coil, B1 inhomogeneity has a substantial impact on data quality. Better coil designs and parallel RF transmission techniques should help to reduce the artifacts caused by B1 inhomogeneity.Funding Sources' NIH grants RR09784, AA12388, AA13521.Relevant publications' D. Mayer, D. M. Spielman Fast 1H Missing-Pulse SSFP Chemical Shift Imaging of the Human Brain at 7 Tesla, Proc ISMRM, 15th Annual Meeting, Berlin, 2007, 771.

National Institute of Health (NIH)
National Center for Research Resources (NCRR)
Biotechnology Resource Grants (P41)
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Maclaren, Julian; Aksoy, Murat; Ooi, Melvyn B et al. (2018) Prospective motion correction using coil-mounted cameras: Cross-calibration considerations. Magn Reson Med 79:1911-1921
Guo, Jia; Holdsworth, Samantha J; Fan, Audrey P et al. (2018) Comparing accuracy and reproducibility of sequential and Hadamard-encoded multidelay pseudocontinuous arterial spin labeling for measuring cerebral blood flow and arterial transit time in healthy subjects: A simulation and in vivo study. J Magn Reson Imaging 47:1119-1132
Kogan, Feliks; Hargreaves, Brian A; Gold, Garry E (2017) Volumetric multislice gagCEST imaging of articular cartilage: Optimization and comparison with T1rho. Magn Reson Med 77:1134-1141
Aksoy, Murat; Maclaren, Julian; Bammer, Roland (2017) Prospective motion correction for 3D pseudo-continuous arterial spin labeling using an external optical tracking system. Magn Reson Imaging 39:44-52
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Lai, Lillian M; Cheng, Joseph Y; Alley, Marcus T et al. (2017) Feasibility of ferumoxytol-enhanced neonatal and young infant cardiac MRI without general anesthesia. J Magn Reson Imaging 45:1407-1418
Taviani, Valentina; Alley, Marcus T; Banerjee, Suchandrima et al. (2017) High-resolution diffusion-weighted imaging of the breast with multiband 2D radiofrequency pulses and a generalized parallel imaging reconstruction. Magn Reson Med 77:209-220
Uecker, Martin; Lustig, Michael (2017) Estimating absolute-phase maps using ESPIRiT and virtual conjugate coils. Magn Reson Med 77:1201-1207
Bian, W; Tranvinh, E; Tourdias, T et al. (2016) In Vivo 7T MR Quantitative Susceptibility Mapping Reveals Opposite Susceptibility Contrast between Cortical and White Matter Lesions in Multiple Sclerosis. AJNR Am J Neuroradiol 37:1808-1815
Vos, Sjoerd B; Aksoy, Murat; Han, Zhaoying et al. (2016) Trade-off between angular and spatial resolutions in in vivo fiber tractography. Neuroimage 129:117-132

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