This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.Recently, steady state free precession (SSFP) chemical shift imaging techniques have been introduced which are particularly attractive because of their short measurement time (Tacq) and high sensitivity (SNR/Tacq). The main disadvantages of SSFP-based methods are that the effects of both T1 and T2 on the signal intensities complicate quantitation and the spectral resolution is limited due to the short TRs. Whereas the former is an inherent problem, the latter is less problematic at high field strengths such as 7 T due to the increased dispersion of the chemical shift. Spectroscopic missing pulse SSFP (spMP-SSFP) has the advantage that the full echo can be acquired. This allows data to be analyzed in magnitude mode without spectral line broadening. Therefore, the aim of this work was to implement spMP-SSFP with a spectral-spatial radiofrequency pulse for combined water and lipid suppression at 7 T. The higher field strength provides better signal separation and higher SNR relative to low- and midfield systems. Even when using a relatively small flip angle (45 ) with the currently available RF coil, B1 inhomogeneity has a substantial impact on data quality. Better coil designs and parallel RF transmission techniques should help to reduce the artifacts caused by B1 inhomogeneity.Funding Sources' NIH grants RR09784, AA12388, AA13521.Relevant publications' D. Mayer, D. M. Spielman Fast 1H Missing-Pulse SSFP Chemical Shift Imaging of the Human Brain at 7 Tesla, Proc ISMRM, 15th Annual Meeting, Berlin, 2007, 771.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Biotechnology Resource Grants (P41)
Project #
5P41RR009784-13
Application #
7601932
Study Section
Special Emphasis Panel (ZRG1-SBIB-F (40))
Project Start
2007-06-01
Project End
2008-05-31
Budget Start
2007-06-01
Budget End
2008-05-31
Support Year
13
Fiscal Year
2007
Total Cost
$57,569
Indirect Cost
Name
Stanford University
Department
Radiation-Diagnostic/Oncology
Type
Schools of Medicine
DUNS #
009214214
City
Stanford
State
CA
Country
United States
Zip Code
94305
Maclaren, Julian; Aksoy, Murat; Ooi, Melvyn B et al. (2018) Prospective motion correction using coil-mounted cameras: Cross-calibration considerations. Magn Reson Med 79:1911-1921
Guo, Jia; Holdsworth, Samantha J; Fan, Audrey P et al. (2018) Comparing accuracy and reproducibility of sequential and Hadamard-encoded multidelay pseudocontinuous arterial spin labeling for measuring cerebral blood flow and arterial transit time in healthy subjects: A simulation and in vivo study. J Magn Reson Imaging 47:1119-1132
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Tamir, Jonathan I; Uecker, Martin; Chen, Weitian et al. (2017) T2 shuffling: Sharp, multicontrast, volumetric fast spin-echo imaging. Magn Reson Med 77:180-195
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Bian, W; Tranvinh, E; Tourdias, T et al. (2016) In Vivo 7T MR Quantitative Susceptibility Mapping Reveals Opposite Susceptibility Contrast between Cortical and White Matter Lesions in Multiple Sclerosis. AJNR Am J Neuroradiol 37:1808-1815
Vos, Sjoerd B; Aksoy, Murat; Han, Zhaoying et al. (2016) Trade-off between angular and spatial resolutions in in vivo fiber tractography. Neuroimage 129:117-132

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