This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Arp2/3 complex is an 223kD assembly of seven proteins that nucleates the growth of actin filaments. This process occurs at the leading enge of motile cells and is thought to play an important role in cell motility. Arp2/3 complex is intrinisically inactive and requires hydrolysable ATP, pre-existing actin fiilament, and one or more activating proteins in order to nucleate filaments.
We aim to understand the function of this complex at the molecular level. The crystal structure of the inactive coplex has been previously solved, and we are currently working on structures of the complex with bound activators and nucleotides to get an idea of how the complex is activated.
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