This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Fanconia Anemia (FA) is a genetic disease that predisposes individuals to incidences of cancer, including leukemia and solid tumors. Moreover, some of FA gene products interact with the components of the BRCA pathway. The key downstream components in the FA pathway are the FA-I and FA-D2 gene products, whose mono-ubiquitinations are thought to be a key event in the repair process. Mutations that affect the mono-ubiquitination of these products or disrupting obligatory association between the two proteins are thought to be causative factors for the disease phenotypes. Thus, structural information for the FA-I/D2 complex is critical in assessing the molecular basis for FA-related cancers and elucidate the DNA repair mechanisms of cross-link and double-stranded break lesions.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Biotechnology Resource Grants (P41)
Project #
5P41RR012408-14
Application #
8170595
Study Section
Special Emphasis Panel (ZRG1-BCMB-R (40))
Project Start
2010-07-01
Project End
2011-06-30
Budget Start
2010-07-01
Budget End
2011-06-30
Support Year
14
Fiscal Year
2010
Total Cost
$2,682
Indirect Cost
Name
Brookhaven National Laboratory
Department
Type
DUNS #
027579460
City
Upton
State
NY
Country
United States
Zip Code
11973
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