This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. As outlined in the request for applications (RFA-DA-04-002) to which we respond here, research that uses rapidly advancing neuro imaging technology to address the effects of drug exposure during development is much needed. We have chosen to investigate this important topic by focusing our efforts on three populations of children, those with prenatal exposure to methamphetamine (MA), those with prenatal exposure to alcohol, and normally developing children without prenatal exposure to drugs of abuse. We will study these populations using structural and functional magnetic resonance imaging, neurocognitive testing, longitudinal data collection, and novel image analyses techniques to assess the following specific aims. 1) To examine brain structural abnormality as a function of prenatal exposure to MA or alcohol, both cross-sectional and longitudinally. 2) To examine differences in brain functional activation between children and adolescents who were exposed to large amounts of MA or alcohol prenatally and those who were not exposed. 3) To examine differences between groups in cognitive functioning using a broad battery of neuropsychological testing instruments. These studies are of critical importance given that very little is known about the effects of prenatal exposure to MA on the developing brain, and MA abuse is rapidly escalating in the United States. Pregnant women are likely among the increased population using this illicit drug, placing an increased sense of importance on our understanding of the consequences of its abuse during pregnancy. To date, there are no published studies describing detailed structural brain abnormalities, functional activation disturbances, or neurocognitive deficits in children with prenatal MA exposure. By comparison, relatively more is known about the teratogenic effects of alcohol on the developing brain, but its abuse during pregnancy is still a significant health problem. The proposal to study two populations with prenatal exposure is critical to our better understanding of the specific neural impact of each drug. This is because the alcohol-exposed individuals will be a better comparison group to assess the effects of prenatal MA exposure, given likely similarities between the groups in pre- and post-natal environments (i.e., nutrition, socioeconomic status, maternal smoking during pregnancy) relative to children without prenatal exposure who are typically studied as a comparison group.
| Green, Shulamite A; Hernandez, Leanna M; Bowman, Hilary C et al. (2018) Sensory over-responsivity and social cognition in ASD: Effects of aversive sensory stimuli and attentional modulation on neural responses to social cues. Dev Cogn Neurosci 29:127-139 |
| Yang, Yaling; Joshi, Shantanu H; Jahanshad, Neda et al. (2017) Neural correlates of proactive and reactive aggression in adolescent twins. Aggress Behav 43:230-240 |
| Dennis, Emily L; Rashid, Faisal; Faskowitz, Josh et al. (2017) MAPPING AGE EFFECTS ALONG FIBER TRACTS IN YOUNG ADULTS. Proc IEEE Int Symp Biomed Imaging 2017:101-104 |
| Walsh, Christine M; Ruoff, Leslie; Walker, Kathleen et al. (2017) Sleepless Night and Day, the Plight of Progressive Supranuclear Palsy. Sleep 40: |
| Green, Shulamite A; Hernandez, Leanna; Bookheimer, Susan Y et al. (2017) Reduced modulation of thalamocortical connectivity during exposure to sensory stimuli in ASD. Autism Res 10:801-809 |
| Flournoy, John C; Pfeifer, Jennifer H; Moore, William E et al. (2016) Neural Reactivity to Emotional Faces May Mediate the Relationship Between Childhood Empathy and Adolescent Prosocial Behavior. Child Dev 87:1691-1702 |
| Joshi, Shantanu H; Vizueta, Nathalie; Foland-Ross, Lara et al. (2016) Relationships Between Altered Functional Magnetic Resonance Imaging Activation and Cortical Thickness in Patients With Euthymic Bipolar I Disorder. Biol Psychiatry Cogn Neurosci Neuroimaging 1:507-517 |
| Ordóñez, Anna E; Loeb, Frances F; Zhou, Xueping et al. (2016) Lack of Gender-Related Differences in Childhood-Onset Schizophrenia. J Am Acad Child Adolesc Psychiatry 55:792-9 |
| Green, Shulamite A; Hernandez, Leanna; Bookheimer, Susan Y et al. (2016) Salience Network Connectivity in Autism Is Related to Brain and Behavioral Markers of Sensory Overresponsivity. J Am Acad Child Adolesc Psychiatry 55:618-626.e1 |
| Kodumuri, Nishanth; Sebastian, Rajani; Davis, Cameron et al. (2016) The association of insular stroke with lesion volume. Neuroimage Clin 11:41-45 |
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