This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Traumatic brain injury patients enrolled into the UCLA Brain Injury Research Center receive multiple brain MRI scans at time of admission, during ICU stay, and again during long-term followup after hospital discharge. Evidence to date demonstrates significant localized and regional white-matter and grey-matter atrophy in increments over time in these patients. We will seek to analyze volumetrics and cortical extractions using the LONI Pipeline V1 in the whole brain and in selected regions by hemisphere, including frontal, basal frontal, hippocampal, parietal and occipital regions, and we will also examine volumes and volume changes in hematoma and perihematomal areas on a case-by-case basis. Resulting volumes and cortical thicknesses will be analyzed by linear mixed modeling and by correlation studies with measures of metabolism and neurological and psychological status obtained in the same patient sample.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Biotechnology Resource Grants (P41)
Project #
5P41RR013642-12
Application #
7955672
Study Section
Special Emphasis Panel (ZRG1-SBIB-L (40))
Project Start
2009-08-01
Project End
2010-07-31
Budget Start
2009-08-01
Budget End
2010-07-31
Support Year
12
Fiscal Year
2009
Total Cost
$13,597
Indirect Cost
Name
University of California Los Angeles
Department
Neurology
Type
Schools of Medicine
DUNS #
092530369
City
Los Angeles
State
CA
Country
United States
Zip Code
90095
Green, Shulamite A; Hernandez, Leanna M; Bowman, Hilary C et al. (2018) Sensory over-responsivity and social cognition in ASD: Effects of aversive sensory stimuli and attentional modulation on neural responses to social cues. Dev Cogn Neurosci 29:127-139
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