This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.Accuracy of quantitative MR imaging-based neuroanatomical study is inherently limited by the acquired image quality such as resolution, distortion, and contrast-to-noise-ratio (CNR). In earlier work, we have developed a high-bandwidth multi-echo FLASH (MEF) pulse sequence that allows significant reduction in image distortion while maintaining high image SNR. In the current phase, we further investigate the benefits provided by this new pulse sequence over other commonly used sequences and develop algorithms to aid in the processing of the new type of image data.
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