The Research Translation Core (RTC) will use effective methods to translate scientific findings and knowledge to those who can take actions to improve public health and protect the environment. The RTC incorporates partnerships with government agencies and communication strategies for broad audiences. a. Addressing the greater susceptibilities of infants and children to environmental exposures ~ Research by Berkeley SRP investigators and others demonstrates greater significance of exposures in early life to the development of disease. Incorporating consideration of critical life stages and susceptibilities into public policy is a critical need. We plan to collaborate with other researchers, US EPA, Cal EPA, and stakeholders to identify critical interventions that arise from the research to date, to translate findings for risk assessment, and to contribute to stable links between groups to amplify impact. b. Improving chemical testing and assessment methods ~ EPA Administrator Jackson has made chemical safety one of her priority areas. New findings and technologies could contribute to better methods to characterize hazards of chemicals at less cost, which would be valuable for assessment of existing Superfund sites and prevention of new ones. The RTC plans to partner with US EPA and Cal EPA to translate new findings in this context and inform our broad audiences through existing networks. c. Reducing cumulative impacts of multiple stressors on communities ~ This is a key priority for US EPA and the Superfund program. Most policy interventions for environmental factors focus on single pollutants. We plan to collaborate with individuals at US EPA Region 9, the Office of Research and Development and the Office of Environmental Justice to contribute to translation of research for methods to consider cumulative impacts of multiple stressors in decisions at the regional and national level. d. Improving remediation for mercury ~ Mercury is a pervasive contaminant ranked third highest among those present at National Priority List sites. Remediation of mercury at Superfund sites is thus a high priority but has had limited successes due to some ofthe unique properties and technological challenges of mercury. We plan to identify ways to over come these challenges. e. The research strategy incorporates paths for technology transfer for each research project. Investigators from Projects will also continue to participate in scientific advisory committees and expert panels and symposia organized by US EPA and other government agencies to transfer and transate scientific results.

Public Health Relevance

The RTC engages the Project Scientists in order to help bring our research to application, policy initiatives, and public awareness. The RTC will partner with local, state, and federal agencies and NGOs to design and implement strategies to translate scientific findings and knowledge on cross-cutting topics in ways that are relevant to their needs.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Hazardous Substances Basic Research Grants Program (NIEHS) (P42)
Project #
5P42ES004705-25
Application #
8382056
Study Section
Special Emphasis Panel (ZES1-SET-V)
Project Start
Project End
Budget Start
2012-04-01
Budget End
2013-03-31
Support Year
25
Fiscal Year
2012
Total Cost
$269,514
Indirect Cost
$89,140
Name
University of California Berkeley
Department
Type
DUNS #
124726725
City
Berkeley
State
CA
Country
United States
Zip Code
94704
Bruton, Thomas A; Sedlak, David L (2018) Treatment of perfluoroalkyl acids by heat-activated persulfate under conditions representative of in situ chemical oxidation. Chemosphere 206:457-464
Schiffman, Courtney; McHale, Cliona M; Hubbard, Alan E et al. (2018) Identification of gene expression predictors of occupational benzene exposure. PLoS One 13:e0205427
Wiemels, Joseph L; Walsh, Kyle M; de Smith, Adam J et al. (2018) GWAS in childhood acute lymphoblastic leukemia reveals novel genetic associations at chromosomes 17q12 and 8q24.21. Nat Commun 9:286
Prasse, Carsten; Ford, Breanna; Nomura, Daniel K et al. (2018) Unexpected transformation of dissolved phenols to toxic dicarbonyls by hydroxyl radicals and UV light. Proc Natl Acad Sci U S A 115:2311-2316
Smith, Allan H; Marshall, Guillermo; Roh, Taehyun et al. (2018) Lung, Bladder, and Kidney Cancer Mortality 40?Years After Arsenic Exposure Reduction. J Natl Cancer Inst 110:241-249
Castriota, Felicia; Acevedo, Johanna; Ferreccio, Catterina et al. (2018) Obesity and increased susceptibility to arsenic-related type 2 diabetes in Northern Chile. Environ Res 167:248-254
Rothman, Nathaniel; Zhang, Luoping; Smith, Martyn T et al. (2018) Formaldehyde, Hematotoxicity, and Chromosomal Changes-Response. Cancer Epidemiol Biomarkers Prev 27:120-121
Yik-Sham Chung, Clive; Timblin, Greg A; Saijo, Kaoru et al. (2018) Versatile Histochemical Approach to Detection of Hydrogen Peroxide in Cells and Tissues Based on Puromycin Staining. J Am Chem Soc 140:6109-6121
Rappaport, Stephen M (2018) Redefining environmental exposure for disease etiology. NPJ Syst Biol Appl 4:30
Tachachartvanich, Phum; Sangsuwan, Rapeepat; Ruiz, Heather S et al. (2018) Assessment of the Endocrine-Disrupting Effects of Trichloroethylene and Its Metabolites Using in Vitro and in Silico Approaches. Environ Sci Technol 52:1542-1550

Showing the most recent 10 out of 629 publications