Abstract

The major focus of this Superfund Program remains the development and validation of in vivo and in vitro bioassays which can be used for risk assessment of oily and wood-preserving wastes. One goal has been to develop and validate a variety of diverse chemical class-specific bioassays that can be utilized for risk assessment of complex toxic mixtures. To achieve this aim, the project has utilized both model compounds and reconstituted mixtures to determine relative potencies of individual congeners and the additive or non-additive interactions which are observed for mixtures. In some studies, the toxic and/or biochemical effects of mixtures obtained from specific hazardous waste sites have also been determined. Progress is reported in determining relative potencies or toxic equivalency factors (TEFs) for some of the most toxic individual compounds that have been identified, and this approach is now being utilized for risk assessment by regulatory agencies worldwide.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Hazardous Substances Basic Research Grants Program (NIEHS) (P42)
Project #
5P42ES004917-10
Application #
2684408
Study Section
Special Emphasis Panel (SRC (G1))
Project Start
1988-12-12
Project End
2000-03-31
Budget Start
1998-04-01
Budget End
1999-03-31
Support Year
10
Fiscal Year
1998
Total Cost
Indirect Cost

  Institution

Name
Texas A&M University
Department
Veterinary Sciences
Type
Schools of Veterinary Medicine
DUNS #
047006379
City
College Station
State
TX
Country
United States
Zip Code
77845

  Publications

Phillips, Tracie D; Richardson, Molly; Cheng, Yi-Shing Lisa et al. (2015) Mechanistic relationships between hepatic genotoxicity and carcinogenicity in male B6C3F1 mice treated with polycyclic aromatic hydrocarbon mixtures. Arch Toxicol 89:967-77
Barhoumi, Rola; Mouneimne, Youssef; Chapkin, Robert S et al. (2014) Effects of fatty acids on benzo[a]pyrene uptake and metabolism in human lung adenocarcinoma A549 cells. PLoS One 9:e90908
dela Cruz, Albert Leo N; Cook, Robert L; Dellinger, Barry et al. (2014) Assessment of environmentally persistent free radicals in soils and sediments from three Superfund sites. Environ Sci Process Impacts 16:44-52
Wlodarczyk, Bogdan J; Zhu, Huiping; Finnell, Richard H (2014) Mthfr gene ablation enhances susceptibility to arsenic prenatal toxicity. Toxicol Appl Pharmacol 275:22-7
Taylor, John F; Robinson, Abraham; Mitchell, Nicole J et al. (2013) In vivo efficacy of ferrihydrite as an enterosorbent for arsenic: short-term evaluation in rodents. J Toxicol Environ Health A 76:167-75
Theodorakis, Christopher W; Bickham, John W; Donnelly, Kirby C et al. (2012) DNA damage in cichlids from an oil production facility in Guatemala. Ecotoxicology 21:496-511
Dash, Bhagirathi; Phillips, Timothy D (2012) Molecular characterization of a catalase from Hydra vulgaris. Gene 501:144-52
Barhoumi, Rola; Mouneimne, Youssef; Ramos, Ernesto et al. (2011) Multiphoton spectral analysis of benzo[a]pyrene uptake and metabolism in a rat liver cell line. Toxicol Appl Pharmacol 253:45-56
Kelley, Matthew A; Gillespie, Annika; Zhou, Guo-Dong et al. (2011) In situ biomonitoring of caged, juvenile Chinook salmon (Oncorhynchus tshawytscha) in the Lower Duwamish Waterway. Mar Pollut Bull 62:2520-32
Rinner, Brian P; Matson, Cole W; Islamzadeh, Arif et al. (2011) Evolutionary toxicology: contaminant-induced genetic mutations in mosquitofish from Sumgayit, Azerbaijan. Ecotoxicology 20:365-76

Showing the most recent 10 out of 268 publications