The investigators propose to examine the interactive accumulation, toxicity, and excretion of Hg, Cd, As, and Cr in rabbit kidney slices and in primary cultures of proximal renal tubular cells grown on porous membrane supports.
The aim i s to determine the effect of exposure to one metal on the kinetics and toxicity of the other metals, using in vitro systems and based on micro-PIXE analyses and biochemical indices of toxicity (e.g., K+/DNA ratio). The effects of certain metal ligands (GSH, MT, albumin) and chelators (DMPS) on the interactions will be tested.

Project Start
1998-04-01
Project End
1999-03-31
Budget Start
1997-10-01
Budget End
1998-09-30
Support Year
9
Fiscal Year
1998
Total Cost
Indirect Cost
Name
University of Arizona
Department
Type
DUNS #
City
Tucson
State
AZ
Country
United States
Zip Code
85721
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