The Research Translation Core (RTC) focuses on improving scientific and public understanding of how Superfund chemicals harm human health and how to reduce exposure to those chemicals, enabling government officials and the public to make informed decisions about reducing risk. We emphasize the high priority Superfund chemicals studied within the UNC SRP. The RTC aims to: (1) foster and coordinate research translation efforts within UNC SRP and share our results with NIEHS and other SRPs, (2) raise awareness of UNC SRP research among federal, state and local government agencies and build their capacity to protect health and the environment around contaminated sites;(3) advance the practical contributions of our research through development of decision support tools and innovative environmental technology;(4) raise awareness among teachers and other broad audiences of UNC SRP research findings and general environmental health concepts related to hazardous chemical exposure;and (5) increase our students'knowledge of research translation concepts. The RTC will continue current efforts to raise awareness of UNC SRP research and extend them to new state agency partners. We will also implement new initiatives designed to respond to research needs identified by state agencies and local health departments in communities with hazardous waste sites. The RTC will continue to assist NCDENR and NCDHHS in creating decision making tools that index cumulative exposure to pollutants and health outcomes, refining beta versions of these tools and implementing new efforts to train agency staff in their use. We will also work with the UNC Office of Technology Development to assist researchers in the commercialization process. In addition, the RTC will continue and expand its teacher professional development activities, enabling us to effectively share Superfund related science with broad audiences in appropriate ways. We will also conduct short courses on research translation topics for Environmental Sciences and Engineering students.

Public Health Relevance

RTC activities will enhance the capacity of federal/state/local agencies to provide technical assistance in communities with identified environmental health concerns. We will contribute to the development of improved decision support tools and cleanup technologies. We will also introduce teachers and others to environmental health concepts, preparing them and their students to make informed decisions in their lives.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Hazardous Substances Basic Research Grants Program (NIEHS) (P42)
Project #
3P42ES005948-21S1
Application #
8885022
Study Section
Special Emphasis Panel (ZES1)
Project Start
Project End
Budget Start
2014-04-01
Budget End
2015-03-31
Support Year
21
Fiscal Year
2014
Total Cost
Indirect Cost
Name
University of North Carolina Chapel Hill
Department
Type
DUNS #
City
Chapel Hill
State
NC
Country
United States
Zip Code
To, Kimberly T; Fry, Rebecca C; Reif, David M (2018) Characterizing the effects of missing data and evaluating imputation methods for chemical prioritization applications using ToxPi. BioData Min 11:10
Dalaijamts, Chimeddulam; Cichocki, Joseph A; Luo, Yu-Syuan et al. (2018) Incorporation of the glutathione conjugation pathway in an updated physiologically-based pharmacokinetic model for perchloroethylene in mice. Toxicol Appl Pharmacol 352:142-152
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Adebambo, Oluwadamilare A; Shea, Damian; Fry, Rebecca C (2018) Cadmium disrupts signaling of the hypoxia-inducible (HIF) and transforming growth factor (TGF-?) pathways in placental JEG-3 trophoblast cells via reactive oxygen species. Toxicol Appl Pharmacol 342:108-115
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Luo, Yu-Syuan; Hsieh, Nan-Hung; Soldatow, Valerie Y et al. (2018) Comparative analysis of metabolism of trichloroethylene and tetrachloroethylene among mouse tissues and strains. Toxicology 409:33-43
Balik-Meisner, Michele; Truong, Lisa; Scholl, Elizabeth H et al. (2018) Population genetic diversity in zebrafish lines. Mamm Genome 29:90-100

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