This collaborative, multidisciplinary, Superfund Hazardous Substances Basic Research Program will study the current urban sources, environmental distribution and toxic effects on human health of lead and persistent chlorinated hydrocarbons--in particular PCBs and DDT. The research Program will be undertaken in New York City. The environment of New York is heavily contaminated with lead and organochlorines. Lead-based paint coats hundreds of bridges and thousands of apartments, and lead is abundant in the sediments of New York Harbor. PCBs contaminate the Hudson River from north of Albany to the bottom of Manhattan, and in consequence of its contamination by PCBs, the lower Hudson is the nation's largest Superfund site. Specific studies in this Program will examine: * The current sources of lead in the Hudson River and New York Harbor. * The mobilization of lead during pregnancy from endogenous skeletal sources in urban women. * The mobilization of lead during surgically induced menopause in urban women and its possible association with neuropsychological dysfunction. * The sources and distribution of chlorinated hydrocarbons in the Hudson River and New York Harbor. * The possibility that chlorinated hydrocarbons in New York harbor sediments exhibit hormonal activity. * The possibility that PCBs or PCB-contaminated harbor sediments may enhance carcinogen metabolism in normal human mammary cells in vitro. These Projects focus on women, children, minority populations and the aging. They will provide a scientifically sound basis for exposure attenuation and disease prevention. They will be supported by an administration core and by support cores providing statistical and data management expertise, stable lead isotope analysis, trace metal analysis and chemical analysis. The Program will also contain a community outreach core for introducing inner-city high school students to environmental studies and a student summer fellowship program in environmental research for college undergraduates.

National Institute of Health (NIH)
National Institute of Environmental Health Sciences (NIEHS)
Hazardous Substances Basic Research Grants Program (NIEHS) (P42)
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Special Emphasis Panel (SRC (G3))
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Mount Sinai School of Medicine
Public Health & Prev Medicine
Schools of Medicine
New York
United States
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Yan, Beizhan; Bopp, Richard F; Abrajano, Teofilo A et al. (2014) Source apportionment of polycyclic aromatic hydrocarbons (PAHs) into Central Park Lake, New York City, over a century of deposition. Environ Toxicol Chem 33:985-92
Miller, Todd R; Colquhoun, David R; Halden, Rolf U (2010) Identification of wastewater bacteria involved in the degradation of triclocarban and its non-chlorinated congener. J Hazard Mater 183:766-72
Miller, Todd R; Heidler, Jochen; Chillrud, Steven N et al. (2008) Fate of triclosan and evidence for reductive dechlorination of triclocarban in estuarine sediments. Environ Sci Technol 42:4570-6
Landrigan, Philip J; Forman, Joel; Galvez, Maida et al. (2008) Impact of September 11 World Trade Center disaster on children and pregnant women. Mt Sinai J Med 75:129-34
Louchouarn, Patrick; Chillrud, Steven N; Houel, Stephane et al. (2007) Elemental and molecular evidence of soot- and char-derived black carbon inputs to New York City's atmosphere during the 20th century. Environ Sci Technol 41:82-7
Grandjean, P; Landrigan, P J (2006) Developmental neurotoxicity of industrial chemicals. Lancet 368:2167-78
Wallenstein, Sylvan; Chen, Jia; Wetmur, James G (2006) Comparison of statistical models for analyzing genotype, inferred haplotype, and molecular haplotype data. Mol Genet Metab 89:270-3
Trasande, Leonardo; Schechter, Clyde; Haynes, Karla A et al. (2006) Applying cost analyses to drive policy that protects children: mercury as a case study. Ann N Y Acad Sci 1076:911-23
Ma, Risheng; Sassoon, David A (2006) PCBs exert an estrogenic effect through repression of the Wnt7a signaling pathway in the female reproductive tract. Environ Health Perspect 114:898-904
Gobeille, Alayne K; Morland, Kimberly B; Bopp, Richard F et al. (2006) Body burdens of mercury in lower Hudson River area anglers. Environ Res 101:205-12

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