This proposal is submitted in response to the Request for Applications (RFA)-ES-05-01, entitled """"""""Superfund Basic Research Program"""""""". The contamination of groundwater and soils with arsenic (As) and manganese (Mn) are associated with major public health, remedial and environmental policy problems. Both Arsenic and manganese are found at numerous Superfund sites. This competitive renewal proposal seeks to obtain new knowledge, train multidisciplinary pre- and post-doctoral students concerning the health effects, geochemistry, and remediation of As and Mn, with a particular focus on groundwater. The proposed work involves substantial work at the single most seriously As-affected Superfund site in Vineland, NJ. It also involves epidemiologic studies of As- and Mn-exposed adults and children residing in Bangladesh and New Hampshire. As in the past, the Columbia University SBRP includes a unique balance between biomedical and non-biomedical research. The proposal includes four biomedical research projects: 1) Genotoxicity and Cell Signaling Pathways of As in Mammalian Cells;2) Health Effects of an As Cohort Study;3) Consequences of As and Mn Exposure on Childhood Intelligence;and 4) One-Carbon Metabolism, Oxidative Stress, and Arsenic Toxicity. The biomedical research is intimately intertwined with three non-biomedical projects: 5) Mobilization of Natural Arsenic in Groundwater;6) Mobilization of Anthropogenic Arsenic in Groundwater;and 7) Mitigation of Arsenic Mobilization in Groundwater. A Research Translation Core entitled, """"""""Collaborating with government and the public: As &Mn exposure via groundwater"""""""" will work with several government agencies to help understand and solve their local groundwater problems. The Projects are supported by four Research Support Cores: 8) Data Management;9) Trace Metals;10) Biogeochemistry;and 11) Hydrogeology. Finally, a Training Core coordinates multi-disciplinary education and interaction among pre- and postdoctoral trainees who benefit from participation in the major inter-disciplinary research program.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Hazardous Substances Basic Research Grants Program (NIEHS) (P42)
Project #
3P42ES010349-10S1
Application #
8068610
Study Section
Special Emphasis Panel (ZES1-SET-A (P9))
Program Officer
Carlin, Danielle J
Project Start
2000-06-01
Project End
2012-03-31
Budget Start
2010-04-30
Budget End
2012-03-31
Support Year
10
Fiscal Year
2010
Total Cost
$118,800
Indirect Cost
Name
Columbia University (N.Y.)
Department
Public Health & Prev Medicine
Type
Schools of Public Health
DUNS #
621889815
City
New York
State
NY
Country
United States
Zip Code
10032
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Wu, Fen; Chi, Liang; Ru, Hongyu et al. (2018) Arsenic Exposure from Drinking Water and Urinary Metabolomics: Associations and Long-Term Reproducibility in Bangladesh Adults. Environ Health Perspect 126:017005
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