This project is concerned with the factors that determine one aspect of human exposure potentials on contaminated sites. The focus is on vapor inhalation potential. The project involves a combined experimental and modeling study, and has a particular emphasis on mixtures and how these influence the exposure processes. The modeling portion of the study involves further development and validation of a threedimensional computational fluid dynamics model that includes the many variables that can play a role in determining exposures. Earlier models of vapor intrusion have often involved simple one-dimensional descriptions of the phenomenon, and are not adequate for describing the actual situation in the field. Likewise, we are interested in examining transient effects that have been explored to a limited degree in such models.
The aim here is to provide a robust tool, based on a commercial computational platform, that will allow regulators and other concerned parties access to modeling results, permitting more effective guiding of site investigation and remediation efforts. This portion of the program will involve close collaboration with our state agency partners, in providing access to new detailed site characterization information necessary for model validation. At the same time, we will continue an experimental examination of many of the factors that play an important role in determining vapor concentrations in mixed environments. The influence of different parts of the actual soil matrix will also be examined for such systems (e.g., black carbons, humic acids, moisture, other free-phase NAPLs).
Specific Aims of this project: 1. To obtain new experimental data on SVOC mixtures of relevance in vapor exposure scenarios. 2. To continue to develop a robust 3-dimensional model of the vapor intrusion phenomenon, including transient effects, complicated geologies, biodegradation and partitioning. 3. Experimentally explore the partitioning of vapors in the subsurface on black carbon, soil, moisture, NAPL/NAPS as an input to the model in 2 above. 4. Work with state partners to validate the modeling approach with real field data, and make the model available to them as a regulatory tool.

Public Health Relevance

The over-arching goal of this Superfund Basic Research Program is to address health concerns, and to design novel remediation techniques, related to mixed exposures arising from contaminated lands and buildings, using Rhode Island as a model for appropriate research, educational, and training interventions. The choice to focus on vapor intrusion reflects the currently very high level of interest in this phenomenon, and will be important in resolving many of the key scientific questions that have been raised regarding this problem.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Hazardous Substances Basic Research Grants Program (NIEHS) (P42)
Project #
5P42ES013660-07
Application #
8249977
Study Section
Special Emphasis Panel (ZES1)
Project Start
Project End
Budget Start
2011-04-01
Budget End
2012-03-31
Support Year
7
Fiscal Year
2011
Total Cost
$214,145
Indirect Cost
Name
Brown University
Department
Type
DUNS #
001785542
City
Providence
State
RI
Country
United States
Zip Code
02912
Guelfo, Jennifer L; Marlow, Thomas; Klein, David M et al. (2018) Evaluation and Management Strategies for Per- and Polyfluoroalkyl Substances (PFASs) in Drinking Water Aquifers: Perspectives from Impacted U.S. Northeast Communities. Environ Health Perspect 126:065001
Chen, Po-Yen; Zhang, Mengke; Liu, Muchun et al. (2018) Ultrastretchable Graphene-Based Molecular Barriers for Chemical Protection, Detection, and Actuation. ACS Nano 12:234-244
Wilson, Shelby; Dere, Edward; Klein, David et al. (2018) Localization of dimethylated histone three lysine four in the Rattus norvegicus sperm genome. Biol Reprod 99:266-268
Kane, Agnes B; Hurt, Robert H; Gao, Huajian (2018) The asbestos-carbon nanotube analogy: An update. Toxicol Appl Pharmacol 361:68-80
Yao, Yijun; Verginelli, Iason; Suuberg, Eric M et al. (2018) Examining the use of USEPA's Generic Attenuation Factor in determining groundwater screening levels for vapor intrusion. Ground Water Monit Remediat 38:79-89
Bianchi, E; Stermer, A; Boekelheide, K et al. (2018) High-quality human and rat spermatozoal RNA isolation for functional genomic studies. Andrology 6:374-383
Toral-Sánchez, E; Rangel-Mendez, J R; Hurt, Robert H et al. (2018) Novel application of magnetic nano-carbon composite as redox mediator in the reductive biodegradation of iopromide in anaerobic continuous systems. Appl Microbiol Biotechnol 102:8951-8961
Thompson, Marcella Remer; Schwartz Barcott, Donna (2018) The Role of the Nurse Scientist as a Knowledge Broker. J Nurs Scholarsh :
Spade, Daniel J; Dere, Edward; Hall, Susan J et al. (2018) All-trans retinoic acid disrupts development in ex vivo cultured fetal rat testes. I: Altered seminiferous cord maturation and testicular cell fate. Toxicol Sci :
Spade, Daniel J; Bai, Cathy Yue; Lambright, Christy et al. (2018) Validation of an automated counting procedure for phthalate-induced testicular multinucleated germ cells. Toxicol Lett 290:55-61

Showing the most recent 10 out of 210 publications