The Brown Superfund Research Program (SRP)-Toxicant Exposures in Rhode Island: Past, Present, and Future-uses its highly successful paradigm of academic-government-community partnerships to tackle environmental health and remediation concerns in Rhode Island, an appropriate geopolitical context for interdisciplinary initiatives. This partnerships model resolves the longstanding problem of how to bring affected parties together to address issues of site contamination by complex mixtures. The scientific theme for this re-submission is Integrated Biomedical & Engineering Solutions to Regulatory Uncertainty, pursued by four projects (two biomedical and two engineering/environmental science) tackling complex issues of past, present and future environmental degradation resulting from legacy chemicals, current discharges, and emerging contaminants. This state-of-the-art research effort addresses key scientific uncertainties facing the Superfund program using the latest research tools, approaches, and technologies in Biomedical-Engineering Project Collaborations (Vapor Intrusion Modeling and Health Monitoring, Nanotechnology Applications and Safety), and within-discipline integration (Biomarkers & Toxicity Testing, Nanomaterial Vapor Barriers). State Agencies Liaisons in Engineering and Environmental Health are a unique feature of the Brown SRP. These positions have enabled the Research Translation Core and Community Engagement Core to develop academic-government-community partnerships with hazardous waste sites contaminated with mixtures of toxicants, both Superfund sites (Centredale Manor Restoration Project, Peterson/Puritan) and Brownfields sites (Fisherville Mill, Gorham/Textron/Mashapaug Pond, Industrial Lane Johnston, and Narragansett Tribal Lands/Waters). The Administrative Core, Training Core, and Molecular Pathology Core support interdisciplinary research and training involving these sites and their contaminants. The Brown SRP provides Rhode Islanders with a responsive center of technical excellence that takes a research-oriented approach to resolving the complex scientific, engineering, and societal issues that are associated with the remediation of hazardous waste sites, by focusing on the following Specific Aims:
Specific Aim 1 : Build on existing strong academic-government-community partnerships to address local environmental health and contaminant remediation issues as a national model of effective intervention at Superfund and Brownfields sites.
Specific Aim 2 : Discover innovative scientific solutions to regulatory uncertainty and environmental contamination by working at the biomedical-engineering interface.
Specific Aim 3 : Pursue interdisciplinary approaches to research, training, and communication to maximize the value and impact of our work locally and nationally.
The Brown Superfund Research Program works to bring the power of academic-government-community partnerships to bear on the scientific uncertainties and challenges at the biomedical-engineering interface raised by the complex contaminants characteristic of Superfund sites. The partnership brings together scientific, regulatory, and social networks in an effort to overcome these challenges and to provide a national model of interdisciplinary engagement in the service of public health and environmental restoration.
|Toral-Sánchez, E; Rangel-Mendez, J R; Hurt, Robert H et al. (2018) Novel application of magnetic nano-carbon composite as redox mediator in the reductive biodegradation of iopromide in anaerobic continuous systems. Appl Microbiol Biotechnol 102:8951-8961|
|Thompson, Marcella Remer; Schwartz Barcott, Donna (2018) The Role of the Nurse Scientist as a Knowledge Broker. J Nurs Scholarsh :|
|Spade, Daniel J; Dere, Edward; Hall, Susan J et al. (2018) All-trans retinoic acid disrupts development in ex vivo cultured fetal rat testes. I: Altered seminiferous cord maturation and testicular cell fate. Toxicol Sci :|
|Spade, Daniel J; Bai, Cathy Yue; Lambright, Christy et al. (2018) Validation of an automated counting procedure for phthalate-induced testicular multinucleated germ cells. Toxicol Lett 290:55-61|
|Sears, Clara G; Braun, Joseph M; Ryan, Patrick H et al. (2018) The association of traffic-related air and noise pollution with maternal blood pressure and hypertensive disorders of pregnancy in the HOME study cohort. Environ Int 121:574-581|
|Guelfo, Jennifer L; Adamson, David T (2018) Evaluation of a national data set for insights into sources, composition, and concentrations of per- and polyfluoroalkyl substances (PFASs) in U.S. drinking water. Environ Pollut 236:505-513|
|Guelfo, Jennifer L; Marlow, Thomas; Klein, David M et al. (2018) Evaluation and Management Strategies for Per- and Polyfluoroalkyl Substances (PFASs) in Drinking Water Aquifers: Perspectives from Impacted U.S. Northeast Communities. Environ Health Perspect 126:065001|
|Chen, Po-Yen; Zhang, Mengke; Liu, Muchun et al. (2018) Ultrastretchable Graphene-Based Molecular Barriers for Chemical Protection, Detection, and Actuation. ACS Nano 12:234-244|
|Wilson, Shelby; Dere, Edward; Klein, David et al. (2018) Localization of dimethylated histone three lysine four in the Rattus norvegicus sperm genome. Biol Reprod 99:266-268|
|Kane, Agnes B; Hurt, Robert H; Gao, Huajian (2018) The asbestos-carbon nanotube analogy: An update. Toxicol Appl Pharmacol 361:68-80|
Showing the most recent 10 out of 210 publications