Evidence suggests that exposure to Superfund chemicals contributes to adverse pregnancy outcomes (APOs), including preterm birth (PTB). Rates of PTB and infant mortality in Puerto Rico (PR) are among the highest of all US states and territories. There are 18 Superfund sites in PR, and evidence of contamination of the drinking water is extensive. Moreover, extreme weather events (hurricanes, flooding) may result in elevated exposures to Superfund chemicals. The PROTECT center has brought together researchers from Northeastern University, the University of Puerto Rico, University of Georgia, and the University of Michigan to provide much needed understanding of the relationship and the mechanisms by which exposure to suspect chemicals contribute to APOs, and to develop new methods to reduce risk of exposure in PR and beyond. To do this, PROTECT uses a source-to-outcome structure, integrating epidemiological (Project 1), toxicological (Project 2), fate and transport (Project 3), and remediation (Project 4) studies, a unified sampling infrastructure, a centralized indexed data repository, and a sophisticated data management system. Since its inception in 2010, PROTECT has built detailed and extensive data sets on environmental conditions and prenatal conditions of 1457 pregnant mothers (exposure, socioeconomic and health data?close to 3000 data points per participant), yielding a cohort of 1210 live births in northern PR. In the renewal, PROTECT will recruit and follow an additional 1000 study participants, yielding a cohort of 800+ live births for an ultimate total cohort of 2000+ completed live births. PROTECT has documented significant contamination of northern PR drinking water and has found compelling preliminary epidemiologic and mechanistic toxicology associations between Superfund chemicals and APOs. PROTECT research has focused on chlorinated volatile organic compounds and phthalates and their role in PTB. The PROTECT renewal will broaden its scope, employing a data-driven approach to study and reduce the impact of exposure to mixtures of suspect chemicals from Superfund sites in karst regions on APOs in Puerto Rico?s underserved, highly-exposed population. Target chemicals will be expanded to include metals, pesticides, and polycyclic aromatic hydrocarbons. We will investigate the impacts of extreme weather events on contaminant transport and exposure, and new water treatment technologies will be developed for portable and robust water treatment systems. The PROTECT renewal will also focus on oxidative stress as an underlying biological pathway by which contaminant exposure can lead to APOs. New statistical methods and data mining, machine learning, and visualization tools will be developed to allow PROTECT researchers to analyze our datasets. PROTECT will employ innovative approaches to engage and educate the community, involve study participants, report- back data, and communicate with stakeholders. A broad suite of training and professional activities will be provided to trainees, individually tailored to the trainees? needs and goals.

Public Health Relevance

Reproductive health has been at the forefront of Puerto Ricans? health concerns as rates of preterm birth and infant mortality in Puerto Rico are among the highest of all U.S. states and territories. The PROTECT SRC is exploring the link between exposure to a mixture of suspect chemicals from Superfund sites and adverse pregnancy outcomes in Puerto Rico, and is working to reduce that exposure. Improved understanding of the link between adverse pregnancy outcomes and contamination, together with developing sustainable technologies to reduce risk, will help improve health outcomes in Puerto Rico (a disadvantaged population) and beyond.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Hazardous Substances Basic Research Grants Program (NIEHS) (P42)
Project #
2P42ES017198-10
Application #
9839906
Study Section
Special Emphasis Panel (ZES1)
Program Officer
Henry, Heather F
Project Start
2010-04-12
Project End
2025-01-31
Budget Start
2020-04-01
Budget End
2021-01-31
Support Year
10
Fiscal Year
2020
Total Cost
Indirect Cost
Name
Northeastern University
Department
Engineering (All Types)
Type
Biomed Engr/Col Engr/Engr Sta
DUNS #
001423631
City
Boston
State
MA
Country
United States
Zip Code
02115
Ferguson, Kelly K; Yu, Youfei; Cantonwine, David E et al. (2018) Foetal ultrasound measurement imputations based on growth curves versus multiple imputation chained equation (MICE). Paediatr Perinat Epidemiol 32:469-473
Boss, Jonathan; Zhai, Jingyi; Aung, Max T et al. (2018) Associations between mixtures of urinary phthalate metabolites with gestational age at delivery: a time to event analysis using summative phthalate risk scores. Environ Health 17:56
Aker, Amira M; Ferguson, Kelly K; Rosario, Zaira Y et al. (2018) The associations between prenatal exposure to triclocarban, phenols and parabens with gestational age and birth weight in northern Puerto Rico. Environ Res 169:41-51
Johns, Lauren E; Ferguson, Kelly K; Cantonwine, David E et al. (2018) Subclinical Changes in Maternal Thyroid Function Parameters in Pregnancy and Fetal Growth. J Clin Endocrinol Metab 103:1349-1358
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Zhou, Wei; Meng, Xiaoxiao; Rajic, Ljiljana et al. (2018) ""Floating"" cathode for efficient H2O2 electrogeneration applied to degradation of ibuprofen as a model pollutant. Electrochem commun 96:37-41
Ashrap, Pahriya; Watkins, Deborah J; Calafat, Antonia M et al. (2018) Elevated concentrations of urinary triclocarban, phenol and paraben among pregnant women in Northern Puerto Rico: Predictors and trends. Environ Int 121:990-1002
Ferguson, Kelly K; Meeker, John D; Cantonwine, David E et al. (2018) Environmental phenol associations with ultrasound and delivery measures of fetal growth. Environ Int 112:243-250
Cathey, Amber; Ferguson, Kelly K; McElrath, Thomas F et al. (2018) Distribution and predictors of urinary polycyclic aromatic hydrocarbon metabolites in two pregnancy cohort studies. Environ Pollut 232:556-562

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