The Animal Behavior Core will provide services, technical assistance and training needed for behavioral testing of mice and rats to satisfy the experimental aims of the investigators within the Research Components of the ACTG. A primary goal of the Animal Behavior Core is to standardize the methods and the analyses for alcohol-related behavioral testing for mice and rats. Core personnel will conduct all homecage drinking studies in mice and rats, and other ethanol-related behavioral tests, as required by the Research Components. The core will instruct research personnel in other behavioral procedures as needed. In addition, the Core will directly compare the rat operant self-administration procedures currently in use by Center Investigators. By conducting a considerable proportion of the behavioral testing within the Core, we ensure that the procedures are performed, and the data are analyzed, in a consistent manner, allowing for maximal comparability of the effects of different experimental manipulations across center projects. This model of centralized behavioral testing by the Animal Behavior Core worked extraordinarily well in the first funding period, allowing for smooth, efficient completion of many behavioral studies. The overall goal of the Animal Behavior Core is to assist Research Components in experiments that test hypotheses regarding the role of novel signaling molecules in alcohol drinking.
The search for new drug targets to develop treatments for alcohol use disorders requires careful testing within preclinical animal models. The Animal Behavior Core will collaborate with Research Components in experiments designed to manipulate excessive ethanol intake and relapse. These studies will seek to increase our understanding of alcohol addiction and open new possibilities for treatment.
|Blasio, Angelo; Wang, Jingyi; Wang, Dan et al. (2018) Novel Small-Molecule Inhibitors of Protein Kinase C Epsilon Reduce Ethanol Consumption in Mice. Biol Psychiatry 84:193-201|
|Fan, Qi Wen; Nicolaides, Theodore P; Weiss, William A (2018) Inhibiting 4EBP1 in Glioblastoma. Clin Cancer Res 24:14-21|
|Barak, Segev; Ahmadiantehrani, Somayeh; Logrip, Marian L et al. (2018) GDNF and alcohol use disorder. Addict Biol :|
|Ron, Dorit; Berger, Anthony (2018) Targeting the intracellular signaling ""STOP"" and ""GO"" pathways for the treatment of alcohol use disorders. Psychopharmacology (Berl) 235:1727-1743|
|Blegen, Mariah B; da Silva E Silva, Daniel; Bock, Roland et al. (2018) Alcohol operant self-administration: Investigating how alcohol-seeking behaviors predict drinking in mice using two operant approaches. Alcohol 67:23-36|
|Vandenberg, Angela; Lin, Wan Chen; Tai, Lung-Hao et al. (2018) Mice engineered to mimic a common Val66Met polymorphism in the BDNF gene show greater sensitivity to reversal in environmental contingencies. Dev Cogn Neurosci 34:34-41|
|Saunders, Benjamin T; Richard, Jocelyn M; Margolis, Elyssa B et al. (2018) Dopamine neurons create Pavlovian conditioned stimuli with circuit-defined motivational properties. Nat Neurosci 21:1072-1083|
|Laguesse, Sophie; Morisot, Nadege; Phamluong, Khanhky et al. (2018) mTORC2 in the dorsomedial striatum of mice contributes to alcohol-dependent F-Actin polymerization, structural modifications, and consumption. Neuropsychopharmacology 43:1539-1547|
|Bird, C W; Baculis, B C; Mayfield, J J et al. (2018) The brain-derived neurotrophic factor VAL68MET polymorphism modulates how developmental ethanol exposure impacts the hippocampus. Genes Brain Behav :e12484|
|Wegner, Scott A; Pollard, Katherine A; Kharazia, Viktor et al. (2017) Limited Excessive Voluntary Alcohol Drinking Leads to Liver Dysfunction in Mice. Alcohol Clin Exp Res 41:345-358|
Showing the most recent 10 out of 75 publications