Abstract

Recent data implicate the K opioid system in ethanol acceptance and reinforcement during infancy and adulthood. Pharmacological blockade of K opioid receptors enhances ethanol intake and reinforcing properties in adult rodents, whereas endogenous activity at K receptors is essential for infants to find ethanol appetitive. Furthermore, activation of the K opioid system is aversive for adult rats. In contrast, in infant rats, central activation of this system is extremely reinforcing. The present proposal will test the hypothesis that the K opioid system switches from mediating appetitive to aversive properties of ethanol between the first and the second postnatal week and that this ontogenetic switch occurs when motivational properties of K opioid activation become aversive instead of appetitive. Finally, changes in the K opioid system following central ethanol administration will be assessed during the first two weeks of postnatal life.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Specialized Center (P50)
Project #
5P50AA017823-04
Application #
8381968
Study Section
Special Emphasis Panel (ZAA1-BB)
Project Start
Project End
Budget Start
2012-09-01
Budget End
2013-08-31
Support Year
4
Fiscal Year
2012
Total Cost
$15,378
Indirect Cost
$4,217

  Institution

Name
State University of NY, Binghamton
Department
Type
DUNS #
090189965
City
Binghamton
State
NY
Country
United States
Zip Code
13902

  Publications

Popoola, Daniel O; Cameron, Nicole M (2018) Maternal care-related differences in males and females rats' sensitivity to ethanol and the associations between the GABAergic system and steroids in males. Dev Psychobiol 60:380-394
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Mooney, Sandra M; Varlinskaya, Elena I (2018) Enhanced sensitivity to socially facilitating and anxiolytic effects of ethanol in adolescent Sprague Dawley rats following acute prenatal ethanol exposure. Alcohol 69:25-32
Lovelock, Dennis F; Deak, Terrence (2018) Neuroendocrine and neuroimmune adaptation to Chronic Escalating Distress (CED): A novel model of chronic stress. Neurobiol Stress 9:74-83
Barney, Thaddeus M; Vore, Andrew S; Gano, Anny et al. (2018) Assessment of Interleukin-6 Signaling Effects on Behavioral Changes Associated with Acute Alcohol Intoxication in adult male rats. Alcohol :
Surkin, P N; Brenhouse, H; Deak, T et al. (2018) Stress, alcohol and infection during early development: A brief review of common outcomes and mechanisms. J Neuroendocrinol 30:e12602
Doremus-Fitzwater, Tamara L; Paniccia, Jacqueline E; Gano, Anny et al. (2018) Differential effects of acute versus chronic stress on ethanol sensitivity: Evidence for interactions on both behavioral and neuroimmune outcomes. Brain Behav Immun 70:141-156
Diaz, Marvin Rafael; Przybysz, Kathryn Renee; Rouzer, Siara K (2018) Age as a factor in stress and alcohol interactions: A critical role for the kappa opioid system. Alcohol 72:9-18
Perkins, Amy E; Vore, Andrew S; Lovelock, Dennis et al. (2018) Late aging alters behavioral sensitivity to ethanol in a sex-specific manner in Fischer 344 rats. Pharmacol Biochem Behav 175:1-9
Akinmboni, T O; Davis, N L; Falck, A J et al. (2018) Excipient exposure in very low birth weight preterm neonates. J Perinatol 38:169-174

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