Abstract

CORE D: NPTMT ABSTRACT The Neuropathology and Targeted Molecular Testing (NPTMT) Core has been a valuable and frequently utilized resource for UW ADRC as it pursues its vision of precision medicine for Alzheimer's disease (AD) as well as for local and national AD research. The mission and thus, specific aims, have not significantly changed from the current award: (i) provide diagnostic expertise, (ii) provide targeted biomarker and genetic testing, (iii) build a highly accessible repository of brain tissue and fluid, (iv) develop innovative approaches, and (v) maintain a rich training environment. All of our research activities are focused on enhancing the research value of tissue and body fluid donations from cognitively healthy individuals and those in the early stages of AD while ensuring proper safeguards.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Specialized Center (P50)
Project #
5P50AG005136-36
Application #
9692536
Study Section
Special Emphasis Panel (ZAG1)
Project Start
Project End
Budget Start
2019-05-01
Budget End
2020-04-30
Support Year
36
Fiscal Year
2019
Total Cost
Indirect Cost

  Institution

Name
University of Washington
Department
Type
DUNS #
605799469
City
Seattle
State
WA
Country
United States
Zip Code
98195

  Publications

Tulloch, Jessica; Leong, Lesley; Thomson, Zachary et al. (2018) Glia-specific APOE epigenetic changes in the Alzheimer's disease brain. Brain Res 1698:179-186
Brenowitz, Willa D; Han, Fang; Kukull, Walter A et al. (2018) Treated hypothyroidism is associated with cerebrovascular disease but not Alzheimer's disease pathology in older adults. Neurobiol Aging 62:64-71
Blue, Elizabeth E; Bis, Joshua C; Dorschner, Michael O et al. (2018) Genetic Variation in Genes Underlying Diverse Dementias May Explain a Small Proportion of Cases in the Alzheimer's Disease Sequencing Project. Dement Geriatr Cogn Disord 45:1-17
Gallagher, Damien; Kiss, Alex; Lanctot, Krista L et al. (2018) Toward Prevention of Mild Cognitive Impairment in Older Adults With Depression: An Observational Study of Potentially Modifiable Risk Factors. J Clin Psychiatry 80:
Reed, May J; Damodarasamy, Mamatha; Pathan, Jasmine L et al. (2018) Increased Hyaluronan and TSG-6 in Association with Neuropathologic Changes of Alzheimer's Disease. J Alzheimers Dis :
Gray, Shelly L; Anderson, Melissa L; Hanlon, Joseph T et al. (2018) Exposure to Strong Anticholinergic Medications and Dementia-Related Neuropathology in a Community-Based Autopsy Cohort. J Alzheimers Dis 65:607-616
Suchy-Dicey, Astrid M; Muller, Clemma J; Madhyastha, Tara M et al. (2018) Telomere Length and Magnetic Resonance Imaging Findings of Vascular Brain Injury and Central Brain Atrophy: The Strong Heart Study. Am J Epidemiol 187:1231-1239
Barnes, Josephine; Bartlett, Jonathan W; Wolk, David A et al. (2018) Disease Course Varies According to Age and Symptom Length in Alzheimer's Disease. J Alzheimers Dis 64:631-642
Nafikov, Rafael A; Nato Jr, Alejandro Q; Sohi, Harkirat et al. (2018) Analysis of pedigree data in populations with multiple ancestries: Strategies for dealing with admixture in Caribbean Hispanic families from the ADSP. Genet Epidemiol 42:500-515
Burke, Shanna L; Maramaldi, Peter; Cadet, Tamara et al. (2018) Decreasing hazards of Alzheimer's disease with the use of antidepressants: mitigating the risk of depression and apolipoprotein E. Int J Geriatr Psychiatry 33:200-211

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