Abstract

The goal of the Data Management Core is to provide an integrated data management and statistical consultation platform for the Cores and Projects in this ADRC and to serve as a provider and an end user for the NACC. The data management team receives, stores, catalogues, tracks and integrates all data generated by the Cores and, when appropriate. Projects, in this ADRC and provides expert advice for the statistical analysis of the existing data and for the design of new studies generated from this ADRC. The data management team also maintains a smooth channel of data submission and data checking for the NACC. The data handling goal will be accomplished by using the specifically designed and well established data warehouse system within the Department of Psychiatry. This system provides access to the contributing projects within the ADRC and the related projects within the Department to integrated data acquisition, storage and query capacity. Because the data warehouse is implemented across multiple projects department-wide, it provides for data access not only to data derived by the specific projects and cores within the ADRC but also to data being derived, and previously acquired legacy data, by many related projects within the Department of Psychiatry network. Most routine data management procedures, such as data entry, logical check and data summary report can be performed automatically with this system. Another mission of the Data Management Core is to provide statistical support to the other Cores and the Projects. The statistical analysis of data generating from the Cores and Projects and the experimental design of new pilot projects in this ADRC are supervised by the Core PI, Dr. Xiaodong Luo and the statistician. Dr. James Schmeidler, who have participated in the planning of the studies and will provide ongoing support throughout the execution of the projects.

Public Health Relevance

The Data Management Core helps smooth and enhance the overall effort of this ADRC in colleting and analyzing data. The Core will work closely with the other Cores and Projects in this ADRC in order to better understand the data.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Specialized Center (P50)
Project #
2P50AG005138-26
Application #
8014549
Study Section
Special Emphasis Panel (ZAG1-ZIJ-4 (J2))
Project Start
Project End
Budget Start
2010-05-01
Budget End
2011-03-31
Support Year
26
Fiscal Year
2010
Total Cost
$143,189
Indirect Cost

  Institution

Name
Icahn School of Medicine at Mount Sinai
Department
Type
DUNS #
078861598
City
New York
State
NY
Country
United States
Zip Code
10029

  Publications

Barnes, Josephine; Bartlett, Jonathan W; Wolk, David A et al. (2018) Disease Course Varies According to Age and Symptom Length in Alzheimer's Disease. J Alzheimers Dis 64:631-642
Gandal, Michael J; Haney, Jillian R; Parikshak, Neelroop N et al. (2018) Shared molecular neuropathology across major psychiatric disorders parallels polygenic overlap. Science 359:693-697
Huckins, L M; Hatzikotoulas, K; Southam, L et al. (2018) Investigation of common, low-frequency and rare genome-wide variation in anorexia nervosa. Mol Psychiatry 23:1169-1180
Schaffert, Jeff; LoBue, Christian; White, Charles L et al. (2018) Traumatic brain injury history is associated with an earlier age of dementia onset in autopsy-confirmed Alzheimer's disease. Neuropsychology 32:410-416
Ki?emet-Piska?, Spomenka; Babi? Leko, Mirjana; Blažekovi?, Antonela et al. (2018) Evaluation of cerebrospinal fluid phosphorylated tau231 as a biomarker in the differential diagnosis of Alzheimer's disease and vascular dementia. CNS Neurosci Ther 24:734-740
Soleimani, Laili; Ravona-Springer, Ramit; Heymann, Anthony et al. (2018) Depression is more strongly associated with cognition in elderly women than men with type 2 diabetes. Int Psychogeriatr :1-5
Burke, Shanna L; Maramaldi, Peter; Cadet, Tamara et al. (2018) Decreasing hazards of Alzheimer's disease with the use of antidepressants: mitigating the risk of depression and apolipoprotein E. Int J Geriatr Psychiatry 33:200-211
Audrain, Mickael; Haure-Mirande, Jean-Vianney; Wang, Minghui et al. (2018) Integrative approach to sporadic Alzheimer's disease: deficiency of TYROBP in a tauopathy mouse model reduces C1q and normalizes clinical phenotype while increasing spread and state of phosphorylation of tau. Mol Psychiatry :
Boban, Mirta; Babi? Leko, Mirjana; Miški?, Terezija et al. (2018) Human neuroblastoma SH-SY5Y cells treated with okadaic acid express phosphorylated high molecular weight tau-immunoreactive protein species. J Neurosci Methods :
Zhu, Carolyn W; Grossman, Hillel; Neugroschl, Judith et al. (2018) A randomized, double-blind, placebo-controlled trial of resveratrol with glucose and malate (RGM) to slow the progression of Alzheimer's disease: A pilot study. Alzheimers Dement (N Y) 4:609-616

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