Abstract

IMAGING CORE The Imaging Core has been significantly strengthened by the recruitments of Arthur Toga, Paul Thompson (INI- Institute for Neuroimaging and Informatics) and Berislav Zlokovic (ZNI-ZIlkha Neurogenetics Institute). Additionally on the pre-clinical side, further institutional support for the ADRC comes with the recruitments of Scott Fraser and Russell Jacobs. Together, these transformational recruits will strengthen the primary mission of the ADRC and its Imaging Core, which is to provide state of the art pre-clinical and clinical imaging acquisition, informatics/image repository and image analysis to this ADRC and the broader AD research community. The Imaging Core has supported a number of federally funded grants as well as Project 1 (Zelinski) and it now plays an important role in supported new Projects 1 (Nation) and 2 (Braskie). INI now provides integration of ALL data between the other cores: Administrative, Clinical, Neuropathology, Data and ORE Cores. Dr. Zlokovic has also led a new direction for the Imaging Core in investigating the role of perfusion MRI and permeability of the blood brain barrier in relation to the pathogenesis of AD. This ties in nicely with the overall vascular mission of the USC ADRC, which is to elucidate vascular contributions to AD.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Specialized Center (P50)
Project #
5P50AG005142-35
Application #
9692621
Study Section
Special Emphasis Panel (ZAG1)
Project Start
Project End
2021-03-31
Budget Start
2019-04-01
Budget End
2020-03-31
Support Year
35
Fiscal Year
2019
Total Cost
Indirect Cost

  Institution

Name
University of Southern California
Department
Type
DUNS #
072933393
City
Los Angeles
State
CA
Country
United States
Zip Code
90089

  Publications

Ramsey, Christine M; Gnjidic, Danijela; Agogo, George O et al. (2018) Longitudinal patterns of potentially inappropriate medication use following incident dementia diagnosis. Alzheimers Dement (N Y) 4:1-10
Sweeney, Melanie D; Kisler, Kassandra; Montagne, Axel et al. (2018) The role of brain vasculature in neurodegenerative disorders. Nat Neurosci 21:1318-1331
Nation, Daniel A (2018) Blood Pressure and Cerebral Blood Flow in Alzheimer Disease. Hypertension 72:68-69
Hadjichrysanthou, Christoforos; McRae-McKee, Kevin; Evans, Stephanie et al. (2018) Potential Factors Associated with Cognitive Improvement of Individuals Diagnosed with Mild Cognitive Impairment or Dementia in Longitudinal Studies. J Alzheimers Dis 66:587-600
Hanfelt, John J; Peng, Limin; Goldstein, Felicia C et al. (2018) Latent classes of mild cognitive impairment are associated with clinical outcomes and neuropathology: Analysis of data from the National Alzheimer's Coordinating Center. Neurobiol Dis 117:62-71
Burke, Shanna L; Hu, Tianyan; Fava, Nicole M et al. (2018) Sex differences in the development of mild cognitive impairment and probable Alzheimer's disease as predicted by hippocampal volume or white matter hyperintensities. J Women Aging :1-25
Wang, Qi; Guo, Lei; Thompson, Paul M et al. (2018) The Added Value of Diffusion-Weighted MRI-Derived Structural Connectome in Evaluating Mild Cognitive Impairment: A Multi-Cohort Validation1. J Alzheimers Dis 64:149-169
Wang, Tingyan; Qiu, Robin G; Yu, Ming (2018) Predictive Modeling of the Progression of Alzheimer's Disease with Recurrent Neural Networks. Sci Rep 8:9161
Agogo, George O; Ramsey, Christine M; Gnjidic, Danijela et al. (2018) Longitudinal associations between different dementia diagnoses and medication use jointly accounting for dropout. Int Psychogeriatr 30:1477-1487
Aydogan, Dogu Baran; Jacobs, Russell; Dulawa, Stephanie et al. (2018) When tractography meets tracer injections: a systematic study of trends and variation sources of diffusion-based connectivity. Brain Struct Funct 223:2841-2858

Showing the most recent 10 out of 590 publications