Abstract

The loss of reproductive cyclicity in aging human females is characterized by a loss in ovarian function and a decline in estrogen and progesterone secretion. There is a corresponding rise in follicle- stimulating hormone and luteinizing hormone in peripheral plasma, suggesting a release of the hypothalamic-pituitary axis from the inhibitory feedback effects of ovarian steroids. It is not known whether this rise in plasma gonadotropins is due to an increase in luteinizing hormone releasing hormone (LHRH) secretion from the hypothalamus or a change in anterior pituitary responsiveness to LHRH. We propose in Pilot 3 to map the distribution of neurons that contain LHRH mRNA in human female hypothalamus. We hope to correlate the dramatic changes in anterior pituitary hormone release in menopause to the levels of hypothalamic mRNA for LHRH. This investigation will lay the groundwork for studying the aging human hypothalamus by examining a well- characterized system with a dramatic functional alteration.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Specialized Center (P50)
Project #
5P50AG005146-09
Application #
3802574
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
9
Fiscal Year
1991
Total Cost
Indirect Cost

  Institution

Name
Johns Hopkins University
Department
Type
DUNS #
045911138
City
Baltimore
State
MD
Country
United States
Zip Code
21218

  Publications

Ayhan, Fatma; Perez, Barbara A; Shorrock, Hannah K et al. (2018) SCA8 RAN polySer protein preferentially accumulates in white matter regions and is regulated by eIF3F. EMBO J 37:
Sathe, Gajanan; Na, Chan Hyun; Renuse, Santosh et al. (2018) Phosphotyrosine profiling of human cerebrospinal fluid. Clin Proteomics 15:29
Chen, Lin; Wei, Zhiliang; Chan, Kannie W Y et al. (2018) Protein aggregation linked to Alzheimer's disease revealed by saturation transfer MRI. Neuroimage 188:380-390
Gomez, Gabriela; Beason-Held, Lori L; Bilgel, Murat et al. (2018) Metabolic Syndrome and Amyloid Accumulation in the Aging Brain. J Alzheimers Dis 65:629-639
Burke, Shanna L; Cadet, Tamara; Maddux, Marlaina (2018) Chronic Health Illnesses as Predictors of Mild Cognitive Impairment Among African American Older Adults. J Natl Med Assoc 110:314-325
Martin, Lee J; Chang, Qing (2018) DNA Damage Response and Repair, DNA Methylation, and Cell Death in Human Neurons and Experimental Animal Neurons Are Different. J Neuropathol Exp Neurol 77:636-655
Kim, Jeongyong; Bandeen-Roche, Karen (2018) Parametric estimation of association in bivariate failure-time data subject to competing risks: sensitivity to underlying assumptions. Lifetime Data Anal :
Bilgel, Murat; An, Yang; Helphrey, Jessica et al. (2018) Effects of amyloid pathology and neurodegeneration on cognitive change in cognitively normal adults. Brain :
Hadjichrysanthou, Christoforos; McRae-McKee, Kevin; Evans, Stephanie et al. (2018) Potential Factors Associated with Cognitive Improvement of Individuals Diagnosed with Mild Cognitive Impairment or Dementia in Longitudinal Studies. J Alzheimers Dis 66:587-600
Yasar, Sevil; Varma, Vijay R; Harris, Gregory C et al. (2018) Associations of Angiotensin Converting Enzyme-1 and Angiotensin II Blood Levels and Cognitive Function. J Alzheimers Dis 63:655-664

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