The Administrative and Biostatistics Core will serve all four projects. The core will be under the direction of Dr. Joseph Buckwalter (Program Director). Dr. Buckwalter will provide overall administrative direction and coordination of all projects. He will also be responsible for facilitating interactions between projects and investigators, in particular the interactions between bioengineers, basic scientists, experts in quantitative joint imaging, rheumatologists and orthopaedic surgeons. He will be responsible for promoting and facilitating the translation of the basic research to patient based studies and clinical practice, and for stimulating new basic research based on new information from the clinical studies. If the need should arise, Dr. Thomas Brown will assume responsibilities of the program director. Lois Lembke, Administrative Assistant II in the Department of Orthopaedic Surgery, has extensive experience in administering grants and departmental programs. She will assist Dr. Buckwalter with the day-to-day administrative details, program coordination and planning and evaluation of the program. Her involvement will facilitate supervision and management of the core unit and individual project budgets. Dr. Stephen L. Hillis, Director of the Statistical Consulting Center, has provided detailed statistical consultation and direction for the development of all of the SCOR projects. He will be responsible for experimental design issues, randomization of experimental units to treatment, monitoring of data collection, and statistical analysis for all projects.

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Specialized Center (P50)
Project #
1P50AR048939-01
Application #
6690444
Study Section
Special Emphasis Panel (ZAR1)
Project Start
2002-09-16
Project End
2007-08-31
Budget Start
Budget End
Support Year
1
Fiscal Year
2002
Total Cost
Indirect Cost
Name
University of Iowa
Department
Type
DUNS #
041294109
City
Iowa City
State
IA
Country
United States
Zip Code
52242
Martin, James A; Anderson, Donald D; Goetz, Jessica E et al. (2017) Complementary models reveal cellular responses to contact stresses that contribute to post-traumatic osteoarthritis. J Orthop Res 35:515-523
Kempton, Laurence B; Dibbern, Kevin; Anderson, Donald D et al. (2016) Objective Metric of Energy Absorbed in Tibial Plateau Fractures Corresponds Well to Clinician Assessment of Fracture Severity. J Orthop Trauma 30:551-6
Anderson, Donald D; Kilburg, Anthony T; Thomas, Thaddeus P et al. (2016) Expedited CT-Based Methods for Evaluating Fracture Severity to Assess Risk of Post-Traumatic Osteoarthritis After Articular Fractures. Iowa Orthop J 36:46-52
Anderson, Donald D; Long, Steven; Thomas, Geb W et al. (2016) Objective Structured Assessments of Technical Skills (OSATS) Does Not Assess the Quality of the Surgical Result Effectively. Clin Orthop Relat Res 474:874-81
Kern, Andrew M; Anderson, Donald D (2015) Expedited patient-specific assessment of contact stress exposure in the ankle joint following definitive articular fracture reduction. J Biomech 48:3427-32
Nguyen, Mai P; Pedersen, Douglas R; Gao, Yubo et al. (2015) Intermediate-term follow-up after ankle distraction for treatment of end-stage osteoarthritis. J Bone Joint Surg Am 97:590-6
Anderson, Donald D; Thomas, Thaddeus P; Campos Marin, Ana et al. (2014) Computational techniques for the assessment of fracture repair. Injury 45 Suppl 2:S23-31
Buckwalter, Joseph A; Anderson, Donald D; Brown, Thomas D et al. (2013) The Roles of Mechanical Stresses in the Pathogenesis of Osteoarthritis: Implications for Treatment of Joint Injuries. Cartilage 4:286-294
Sauter, Ellen; Buckwalter, Joseph A; McKinley, Todd O et al. (2012) Cytoskeletal dissolution blocks oxidant release and cell death in injured cartilage. J Orthop Res 30:593-8
Saltzman, Charles L; Hillis, Stephen L; Stolley, Mary P et al. (2012) Motion versus fixed distraction of the joint in the treatment of ankle osteoarthritis: a prospective randomized controlled trial. J Bone Joint Surg Am 94:961-70

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