Abstract

We propose a Joint Trauma Biomarker Core to oversee all molecular biomarker studies proposed in CORT projects. The Core will provide crucial technical support in the form of validated assays for the OARSI-recommended biomarkers proposed in Projects 2 and 3. In addition, the Core will establish and maintain a comprehensive repository of synovial fluids and sera from animals and patients. This repository will be accessed for advanced biomarker studies predicated on new findings emerging from CORT research. Finally, the Core will foster the development of novel mathematical models of joint injuries for testing functional relationships between biomarkers and joint degeneration. Thus, in addition to assay services the Core will offer resources for testing new biomarker-related hypotheses that flow from CORT discoveries.

Public Health Relevance

Synovial fluid and serum biomarkers will be collected and studied in CORT projects to better understand their relationship to OA in various injury scenarios. The overall goal of the Joint Trauma Biomarker Core will be to realize the immense potential for biomarker discovery embodied in these large, fully documented sample collections. This will require close coordination among different labs and investigators, a need best filled by a centralized Core.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Specialized Center (P50)
Project #
5P50AR055533-07
Application #
8539466
Study Section
Special Emphasis Panel (ZAR1-KM)
Project Start
Project End
Budget Start
2013-09-01
Budget End
2014-08-31
Support Year
7
Fiscal Year
2013
Total Cost
$200,583
Indirect Cost
$64,398

  Institution

Name
University of Iowa
Department
Type
DUNS #
062761671
City
Iowa City
State
IA
Country
United States
Zip Code
52242

  Publications

Seol, Dongrim; Tochigi, Yuki; Bogner, Ashley M et al. (2018) Effects of knockout of the receptor for advanced glycation end-products on bone mineral density and synovitis in mice with intra-articular fractures. J Orthop Res 36:2439-2449
Thomas-Aitken, Holly D; Willey, Michael C; Goetz, Jessica E (2018) Joint contact stresses calculated for acetabular dysplasia patients using discrete element analysis are significantly influenced by the applied gait pattern. J Biomech 79:45-53
Coleman, Mitchell C; Goetz, Jessica E; Brouillette, Marc J et al. (2018) Targeting mitochondrial responses to intra-articular fracture to prevent posttraumatic osteoarthritis. Sci Transl Med 10:
Townsend, Kevin C; Thomas-Aitken, Holly D; Rudert, M James et al. (2018) Discrete element analysis is a valid method for computing joint contact stress in the hip before and after acetabular fracture. J Biomech 67:9-17
Martin, James A; Anderson, Donald D; Goetz, Jessica E et al. (2017) Complementary models reveal cellular responses to contact stresses that contribute to post-traumatic osteoarthritis. J Orthop Res 35:515-523
Freeman, Katie; Michalson, Jared L; Anderson, Donald D et al. (2017) Tibial Plateau Fractures: A New Rank Ordering Method For Determining To What Degree Injury Severity Or Quality Of Reduction Correlate With Clinical Outcome. Iowa Orthop J 37:57-63
Ayati, Bruce P; Kapitanov, Georgi I; Coleman, Mitchell C et al. (2017) Mathematics as a conduit for translational research in post-traumatic osteoarthritis. J Orthop Res 35:566-572
Wang, S; Zhou, C; Zheng, H et al. (2017) Chondrogenic progenitor cells promote vascular endothelial growth factor expression through stromal-derived factor-1. Osteoarthritis Cartilage 25:742-749
Seol, Dongrim; Zhou, Cheng; Brouillette, Marc J et al. (2017) Characteristics of meniscus progenitor cells migrated from injured meniscus. J Orthop Res 35:1966-1972
Goetz, Jessica E; Coleman, Mitchell C; Fredericks, Douglas C et al. (2017) Time-dependent loss of mitochondrial function precedes progressive histologic cartilage degeneration in a rabbit meniscal destabilization model. J Orthop Res 35:590-599

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