The objectives of this core facility are (1) To maintain a comprehensive bank of frozen and fixed breast carcinoma and normal breast tissues from patients with follow-up information for use by SPORE investigators and other relevant groups including other SPORES. (2) To provide comprehensive tissue procurement, histologic, and tissue processing services, and (3) to provide expert assistance in Conducting experiments using specimens from human and animal subjects, including assistance in interpreting immunohistochemical and In-situ hybridization studies. The Tumor Bank began operations in 1991 under the Direction of Dr. Soonmyoung Paik, a board certified pathologist (anatomic pathology) with a number of publications in the area of breast carcinoma. Since October of 1993, Dr. Elizabeth Montgomery, a service-oriented pathologist (board certified in anatomic, clinical, and cytopathology), assumed the responsibility for the daily operations of the Tumor Bank. Based on Dr. Paik's experience in breast carcinoma pathology, which includes successful collaborations with the NSABP and the Yonsei Cancer Center, he remains the Tumor Bank Co-Director and continues to function as an active consultant to all SPORE investigators in both the current and proposed SPORE. The Tumor Bank works closely with the other Core Facilities and provides a full range of tissue processing and procurement services.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Specialized Center (P50)
Project #
3P50CA058185-07S2
Application #
6102813
Study Section
Project Start
1998-07-28
Project End
1998-08-15
Budget Start
Budget End
Support Year
7
Fiscal Year
1998
Total Cost
Indirect Cost
Name
Georgetown University
Department
Type
DUNS #
049515844
City
Washington
State
DC
Country
United States
Zip Code
20057
Sharif, G M; Schmidt, M O; Yi, C et al. (2015) Cell growth density modulates cancer cell vascular invasion via Hippo pathway activity and CXCR2 signaling. Oncogene 34:5879-89
Rosenfield, Sonia M; Bowden, Emma T; Cohen-Missner, Shani et al. (2012) Pleiotrophin (PTN) expression and function and in the mouse mammary gland and mammary epithelial cells. PLoS One 7:e47876
Wellstein, Anton; Toretsky, Jeffrey A (2011) Hunting ALK to feed targeted cancer therapy. Nat Med 17:290-1
Hu, Zhang-Zhi; Kagan, Benjamin L; Ariazi, Eric A et al. (2011) Proteomic analysis of pathways involved in estrogen-induced growth and apoptosis of breast cancer cells. PLoS One 6:e20410
Stylianou, D C; Auf der Maur, A; Kodack, D P et al. (2009) Effect of single-chain antibody targeting of the ligand-binding domain in the anaplastic lymphoma kinase receptor. Oncogene 28:3296-306
Coticchia, Christine M; Revankar, Chetana M; Deb, Tushar B et al. (2009) Calmodulin modulates Akt activity in human breast cancer cell lines. Breast Cancer Res Treat 115:545-60
Gibby, Krissa A; McDonnell, Kevin; Schmidt, Marcel O et al. (2009) A distinct role for secreted fibroblast growth factor-binding proteins in development. Proc Natl Acad Sci U S A 106:8585-90
Deb, Tushar B; Coticchia, Christine M; Barndt, Robert et al. (2008) Pregnancy-upregulated nonubiquitous calmodulin kinase induces ligand-independent EGFR degradation. Am J Physiol Cell Physiol 295:C365-77
Veselik, David J; Divekar, Shailaja; Dakshanamurthy, Sivanesan et al. (2008) Activation of estrogen receptor-alpha by the anion nitrite. Cancer Res 68:3950-8
Bullitt, Elizabeth; Lin, Nancy U; Smith, J Keith et al. (2007) Blood vessel morphologic changes depicted with MR angiography during treatment of brain metastases: a feasibility study. Radiology 245:824-30

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