Abstract

This application for continuation of the Specialized Program of Research Excellence (SPORE) in Gastrointestinal Cancer at the Johns Hopkins Medical Institutions supports a highly interactive, multidisciplinary, and interinstitutional program. Eight research projects within four research programs, four cores, a career development and a research developmental program are proposed to further our translational research in colorectal and pancreatic cancer. Research Program 1: Applied Cancer Genetics (0012, Diagnosis and prognosis of human cancers through molecular genetic analyses, Dr. Kenneth Kinzler; 0002, New genetic clues in pancreatic cancer, Dr. Scott Kern). Program 2: Markers of Tumorigenesis (0013, Components of early and late pancreatic neoplasia, Dr. Scott Kern; 0008, Screening markers for high pancreatic cancer susceptibility, Dr. Michael Goggins). Program 3: Assessment of Familial Risk- (0014, Risk prediction in familial colorectal cancer, Dr. Giovanni Parmigiani; 0011, Markers for risk in familial pancreatic cancer, Dr. Ralph Hruban). Program 4: Therapeutic Directions (0015, Chemoprevention of human colorectal tumors, Dr. David Huso; 0016, Integration of chemotherapy with vaccination in metastatic pancreatic cancer, Dr. Elizabeth Jaffee). The cores support the research programs ( 9002, Human Tissue Research and Logistics, Dr. Elizabeth Montgomery; 9003, Familial Cancer Registries, Dr. Frank Giardiello; 9004, Statistics/Bioinformatics, Dr. Steven Goodman. The Career Development Program (Dr. Scott Kern) aids the emergence of new investigators and the Research Developmental Program (Dr. Bert Vogelstein) provides rapid funding of innovative directions.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Specialized Center (P50)
Project #
5P50CA062924-10
Application #
6631424
Study Section
Special Emphasis Panel (ZCA1-GRB-V (J1))
Program Officer
Agarwal, Rajeev K
Project Start
1993-09-30
Project End
2007-06-30
Budget Start
2003-07-01
Budget End
2004-06-30
Support Year
10
Fiscal Year
2003
Total Cost
$2,788,126
Indirect Cost

  Institution

Name
Johns Hopkins University
Department
Pathology
Type
Schools of Medicine
DUNS #
001910777
City
Baltimore
State
MD
Country
United States
Zip Code
21218

  Publications

Li, Yuguo; Qiao, Yuan; Chen, Hanwei et al. (2018) Characterization of tumor vascular permeability using natural dextrans and CEST MRI. Magn Reson Med 79:1001-1009
Saung, May Tun; Muth, Stephen; Ding, Ding et al. (2018) Targeting myeloid-inflamed tumor with anti-CSF-1R antibody expands CD137+ effector T-cells in the murine model of pancreatic cancer. J Immunother Cancer 6:118
Canto, Marcia Irene; Almario, Jose Alejandro; Schulick, Richard D et al. (2018) Risk of Neoplastic Progression in Individuals at High Risk for Pancreatic Cancer Undergoing Long-term Surveillance. Gastroenterology 155:740-751.e2
Makohon-Moore, Alvin P; Matsukuma, Karen; Zhang, Ming et al. (2018) Precancerous neoplastic cells can move through the pancreatic ductal system. Nature 561:201-205
Chu, Nam; Salguero, Antonieta L; Liu, Albert Z et al. (2018) Akt Kinase Activation Mechanisms Revealed Using Protein Semisynthesis. Cell 174:897-907.e14
Felsenstein, Matthäus; Noë, Michaël; Masica, David L et al. (2018) IPMNs with co-occurring invasive cancers: neighbours but not always relatives. Gut 67:1652-1662
Grant, Robert C; Denroche, Robert E; Borgida, Ayelet et al. (2018) Exome-Wide Association Study of Pancreatic Cancer Risk. Gastroenterology 154:719-722.e3
Tie, Jeanne; Cohen, Joshua D; Wang, Yuxuan et al. (2018) Serial circulating tumour DNA analysis during multimodality treatment of locally advanced rectal cancer: a prospective biomarker study. Gut :
Adler, B L; Pezhouh, M K; Kim, A et al. (2018) Histopathological and immunophenotypic features of ipilimumab-associated colitis compared to ulcerative colitis. J Intern Med 283:568-577
Ma, Qianqian; Gabelli, Sandra B; Raben, Daniel M (2018) Diacylglycerol kinases: Relationship to other lipid kinases. Adv Biol Regul :

Showing the most recent 10 out of 883 publications