The Dana-Farber/Harvard Cancer Center (DF/HCC) SPORE in Prostate Cancer Biostatistics and Computational Biology Core collaborates and provides consultation on all research activities within the SPORE, including SPORE Projects, Developmental Projects, Projects of the Career Development Awardees, and other SPORE Cores, to ensure the highest standards of scientific rigor in areas of study design, data management and integrity, and data analysis and interpretation.
The specific aims are to: 1. Provide biostatistical and computational biology expertise for the planning and design, conduct, analysis, and reporting of laboratory, genomic, animal, translational, clinical (including associated correlative studies), and epidemiological studies for SPORE projects. Developmental Projects, Projects of the Career Development Awardees, and other SPORE Cores. 2. Provide consultation on all issues of data management and integrity, including data collection, storage, transfer and quality assurance, on statistical and computational biology software and programs, and on coordination of laboratory results with parameters and outcomes from clinical studies or clinical/translational research databases. 3. Provide short-term biostatistics and computational biology consulting to the entire group of SPORE researchers.

Public Health Relevance

The Biostatistics and Computational Biology Core is an integral part of research activities within the DF/HCC SPORE in Prostate Cancer. The Core's objective is to ensure the highest standards of scientific rigor in areas of study design, data integrity, and data analysis and interpretation.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Specialized Center (P50)
Project #
5P50CA090381-12
Application #
8764826
Study Section
Special Emphasis Panel (ZCA1)
Project Start
Project End
Budget Start
2014-07-01
Budget End
2015-06-30
Support Year
12
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Dana-Farber Cancer Institute
Department
Type
DUNS #
City
Boston
State
MA
Country
United States
Zip Code
02215
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Russo, Joshua W; Gao, Ce; Bhasin, Swati S et al. (2018) Downregulation of Dipeptidyl Peptidase 4 Accelerates Progression to Castration-Resistant Prostate Cancer. Cancer Res 78:6354-6362
Sowalsky, Adam G; Ye, Huihui; Bhasin, Manoj et al. (2018) Neoadjuvant-Intensive Androgen Deprivation Therapy Selects for Prostate Tumor Foci with Diverse Subclonal Oncogenic Alterations. Cancer Res 78:4716-4730

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