The University of Pittsburgh proposes to continue a Specialized Program of Research Excellence (SPORE) in Head and Neck Cancer. The overall goals of the Head and Neck SPORE are to improve the prevention and treatment of head and neck cancer as well as the detection and treatment of thyroid cancer (new in this renewal). The SPORE program consists of four translational research projects, 3 focused on head and neck squamous cell carcinoma (HNSCC) and one focused on thyroid cancer, two research cores, an administrative core, a developmental research program and a career development program. The SPORE will use an interdisciplinary approach to meet its objectives by carrying out projects jointly led by investigators in basic, applied and clinical science. The long-term goal of the Head and Neck SPORE is to conduct clinical studies based on research results from the translational research projects that will serve as the basis for improving the outcome of individuals diagnosed with head and neck cancers. The four main projects include: (1) Chemoprevention of Head and Neck Cancer; (2) Optimization of STAT3 Decoy Delivery for Head and Neck Cancer Treatment; (3) Checkpoint Receptor Targeting to Enhance Cetuximab Efficacy Against HNSCC; and (4) Molecular-Guided Risk Stratification of Thyroid Nodules and Cancer. The three cores will interact closely to assist the main research projects, developmental research projects and career development investigators in carrying out translational head and neck cancer research. The research cores include: (a) Histology/Tissue and (b) Informatics, Biostatistics and Bioinformatics. The Administrative Core will solicit feedback from the Internal and External Scientific Advisory Boards and provide scientific, regulatory and fiscal oversight for the SPORE program. The Head and Neck SPORE investigators will work together to synergistically achieve the goals of the program and will also continue to interact closely with investigators from other Head and Neck and Thyroid SPOREs at other institutions, as well as the cooperative groups, to improve the outcome of patients with cancers of the head and neck.

Public Health Relevance

The goal of this application is to use a multi-disciplinary approach to improve the management and outcomes in head and neck cancers including head and neck squamous cell carcinoma and thyroid cancer. We will advance the prevention and treatment for head and neck squamous cell cancer patients by identifying new ways to prevent and treat the disease based on the biology of the individual patient's tumor and new biomarkers that predict risk and response to therapy. We will advance the management of thyroid nodules and thyroid cancer by integrating novel next generation sequencing platforms into clinical strategies.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Specialized Center (P50)
Project #
5P50CA097190-13
Application #
9319632
Study Section
Special Emphasis Panel (ZCA1)
Program Officer
Hubbard, Leah
Project Start
2004-07-01
Project End
2020-06-30
Budget Start
2017-07-01
Budget End
2018-06-30
Support Year
13
Fiscal Year
2017
Total Cost
Indirect Cost
Name
University of Pittsburgh
Department
Otolaryngology
Type
Schools of Medicine
DUNS #
004514360
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213
Lee, Yoon Se; Johnson, Daniel E; Grandis, Jennifer R (2018) An update: emerging drugs to treat squamous cell carcinomas of the head and neck. Expert Opin Emerg Drugs :1-17
Johnson, Daniel E; O'Keefe, Rachel A; Grandis, Jennifer R (2018) Targeting the IL-6/JAK/STAT3 signalling axis in cancer. Nat Rev Clin Oncol 15:234-248
Close, David A; Camarco, Daniel P; Shan, Feng et al. (2018) The Generation of Three-Dimensional Head and Neck Cancer Models for Drug Discovery in 384-Well Ultra-Low Attachment Microplates. Methods Mol Biol 1683:355-369
Yang, Xi; Xia, Rui; Yue, Cuihua et al. (2018) ATF4 Regulates CD4+ T Cell Immune Responses through Metabolic Reprogramming. Cell Rep 23:1754-1766
Njatcha, Christian; Farooqui, Mariya; Kornberg, Adam et al. (2018) STAT3 Cyclic Decoy Demonstrates Robust Antitumor Effects in Non-Small Cell Lung Cancer. Mol Cancer Ther 17:1917-1926
Johnston, Paul A; Sen, Malabika; Hua, Yun et al. (2018) High Content Imaging Assays for IL-6-Induced STAT3 Pathway Activation in Head and Neck Cancer Cell Lines. Methods Mol Biol 1683:229-244
Palliyaguru, Dushani L; Yuan, Jian-Min; Kensler, Thomas W et al. (2018) Isothiocyanates: Translating the Power of Plants to People. Mol Nutr Food Res 62:e1700965
Gleber-Netto, Frederico O; Zhao, Mei; Trivedi, Sanchit et al. (2018) Distinct pattern of TP53 mutations in human immunodeficiency virus-related head and neck squamous cell carcinoma. Cancer 124:84-94
Santuray, Rodell T; Johnson, Daniel E; Grandis, Jennifer R (2018) New Therapies in Head and Neck Cancer. Trends Cancer 4:385-396
Liu, Zhuqing; McMichael, Elizabeth L; Shayan, Gulidanna et al. (2018) Novel Effector Phenotype of Tim-3+ Regulatory T Cells Leads to Enhanced Suppressive Function in Head and Neck Cancer Patients. Clin Cancer Res 24:4529-4538

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